VIRUS-SPECIFIC FACTORS IN EXPERIMENTAL ARGENTINE HEMORRHAGIC-FEVER IN RHESUS MACAQUES
VIRUS-SPECIFIC FACTORS IN EXPERIMENTAL ARGENTINE HEMORRHAGIC-FEVER IN RHESUS MACAQUES
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DOI：
10.1002/jmv.1890220202
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发表时间：
1987-06-01
影响因子：
12.7
通讯作者：
PETERS, CJ
中科院分区：
文献类型：
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作者：
MCKEE, KT;MAHLANDT, BG;PETERS, CJ
阿根廷出血热的一种非人类灵长类动物模型已经被开发出来，它与人类临床综合征非常相似。成年猕猴经肠外感染两种低传代Junin病毒株，导致恒河猴出现独特的出血性或神经系统疾病，这与获得该病毒株的人的临床疾病模式相关。在感染两种病毒株的动物中，记录了短暂的白细胞减少症，以及血小板减少症和继发性细菌性败血症。相反，在两个病毒感染组中出现了不同的病毒血症、口咽病毒脱落和抗体反应模式。这些结果，连同死后的病毒学和组织病理学发现，表明病毒株特异性因素是该模型系统中临床疾病模式的重要决定因素。
A nonhuman primate model for Argentine hemorrhagic fever has been developed that closely mimics the human clinical syndrome. Parenteral infection of adult Macaca mulatta with low-passage isolates of two Junin viral strains resulted in distinctive hemorrhagic or neurological disease in rheusus macaques that correlated with clinical illness patterns present in the humans from whom the viral strains were obtained. Transient leukopenia, together with thrombocytopenia and secondary bacterial septicemia, were documented among animals infected with both viral strains. In contrast, differing patterns of viremia, oropharyngeal viral shedding, and antibody response occurred in the two virus-infected groups. These results, together with postmortem virologic and histopathologic findings, suggest that viral-strain-specific factors are important determinants of clinical disease patterns in this model system.