Reactivation of Toxoplasma gondii by cytomegalovirus disease in mice: antimicrobial activities of macrophages.
Reactivation of Toxoplasma gondii by cytomegalovirus disease in mice: antimicrobial activities of macrophages.
复制标题
小鼠巨细胞病毒病对弓形虫的再激活：巨噬细胞的抗菌活性。
DOI：
10.1093/infdis/160.2.305
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发表时间：
1989
期刊：
影响因子：
--
通讯作者：
Filice,GA
中科院分区：
文献类型：
--
作者：
Pomeroy,C;Kline,S;Jordan,MC;Filice,GA
在免疫功能低下的患者中，刚地弓形虫感染的再激活通常与巨细胞病毒（CMV）疾病同时发生，巨细胞病毒疾病导致免疫抑制。确定小鼠巨细胞病毒（MCMV）感染是否会降低对t的抵抗力。弓形虫，携带潜伏t病毒的老鼠。弓形虫感染均感染mcmvt。刚地虫感染再次激活，主要表现为肺炎。肺巨噬细胞支持细胞生长。在t之前，t期间和t之后。gondiireactivation。腹腔巨噬细胞抑制ofT生长。刚地虫肺炎随着肺炎的消退而发展为容许性肺炎。携带潜伏t病毒的老鼠。与对照组相比，感染弓形虫的人可以在更大剂量的MCMV中存活。因此，MCMV感染导致潜伏t的再激活。小鼠刚地虫感染。肺巨噬细胞的激活，通过它们抑制ofT复制的能力来评估。体外gondiiin，与控制gondiii感染无关。
Reactivation ofToxoplasma gondiiinfection often occurs concurrently with active cytomegalovirus (CMV) disease in immunocompromised patients, and CMV disease results in immunosuppression. To determine if murine CMV (MCMV) infection decreases resistance toT. gondii,mice with latentT. gondiiinfection were infected with MCMV.T. gondiiinfection reactivated, manifested primarily as pneumonia. Lung macrophages supported the growth ofT. gondiibefore, during, and afterT. gondiireactivation. Peritoneal macrophages inhibited the growth ofT. gondiias pneumonia developed and became permissive as pneumonia resolved. Mice with latentT. gondiiinfection could survive larger doses of MCMV than could controls. Thus, MCMV infection led to reactivation of latentT. gondiiinfection in mice. Activation of lung macrophages, assessed by their ability to inhibit replication ofT.gondiiin vitro, was not associated with control ofT.gondiiinfection.