Numerous isoforms of Fgf8 reflect its multiple roles in the developing brain.
Numerous isoforms of Fgf8 reflect its multiple roles in the developing brain.
复制标题
Fgf8 的多种亚型反映了其在大脑发育中的多重作用。
DOI：
10.1002/jcp.22587
复制
发表时间：
2011
影响因子：
5.6
通讯作者：
Li,JamesYH
中科院分区：
文献类型：
--
作者：
Sunmonu,NAbimbola;Li,Kairong;Li,JamesYH
成纤维细胞生长因子（Fibroblastgrowthfactors，FGF）是一类广泛存在于线虫和人类等多种生物体内的多肽生长因子，在多细胞生物发育过程中对细胞的增殖、分化、命运决定和形态发生起着重要的调节和整合作用。FGF及其受体的RNA选择性剪接进一步增强了这种配体-受体系统的复杂性。小鼠Fgf 8基因产生八种剪接变体，其编码具有不同N末端和不同受体结合亲和力和生物活性的同种型蛋白。本文综述了Fgf 8在脊椎动物发育中的作用，并对Fgf 8不同剪接变体在体内的功能进行了综述。我们认为多种Fgf 8亚型蛋白协同作用调节Fgf 8的整体功能，并解释了Fgf 8在脊椎动物发育过程中的多样性和重要作用。J.细胞。226：1722-1726，2011。© 2010 Wiley利斯公司
Soluble growth factors play an important role in the coordination and integration of cell proliferation, differentiation, fate determination, and morphogenesis during development of multicellular organisms.Fibroblastgrowthfactors (FGFs) are a large family of polypeptide growth factors that are present in organisms ranging from nematodes to humans. RNA alternative splicing of FGFs and their receptors further enhances the complexity of this ligand‐receptor system. The mouseFgf8gene produces eight splice variants, which encode isoform proteins with different N‐termini and distinct receptor‐binding affinity and biological activity. In this article, we review the roles ofFgf8in vertebrate development and summarize the recent findings on the in vivo function of differentFgf8splice variants. We propose that multiple Fgf8 isoform proteins act in concert to regulate the overall function ofFgf8and account for the diverse and essential role ofFgf8during vertebrate development. J. Cell. Physiol. 226: 1722–1726, 2011. © 2010 Wiley‐Liss, Inc.