Day-night variations of serum interleukin-6 in patients with severe obstructive sleep apnea syndrome before and after continuous positive airway pressure (CPAP)
Day-night variations of serum interleukin-6 in patients with severe obstructive sleep apnea syndrome before and after continuous positive airway pressure (CPAP)
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DOI：
10.1080/07420520802384101
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发表时间：
2008-01-01
影响因子：
2.8
通讯作者：
Shimizu, Eiji
中科院分区：
文献类型：
--
作者：
Burioka, Naoto;Miyata, Masanori;Shimizu, Eiji
阻塞性睡眠呼吸暂停综合征（OSAS）引起间歇性缺氧和交感神经活动增加，并导致心血管疾病。白细胞介素-6（IL-6）是重要的促炎细胞因子之一。我们检测了9例重度OSAS患者在持续气道正压通气（CPAP）治疗3个月前后24小时内4个不同时间点的血清IL-6浓度。CPAP治疗后血清IL-6水平显著降低46%（6.21.0 vs. 3.30.4pg/ml，p0.005）。重度OSAS患者CPAP治疗前血清IL-6水平无明显变化，而CPAP治疗后血清IL-6水平明显升高。睡眠中间歇性缺氧可能导致全身炎症反应，并导致血清IL-6升高。
Obstructive sleep apnea syndrome (OSAS) causes intermittent hypoxia and increases in sympathetic activity and contributes to cardiovascular disorders. Interleukin-6 (IL-6) is one of the important proinflammatory cytokines. We examined the levels of serum IL-6 concentrations in nine patients with severe OSAS at four different clock times during the 24h before and after three months of continuous positive airway pressure (CPAP) therapy. Serum IL-6 levels were significantly reduced after CPAP therapy by 46% (6.21.0 vs. 3.30.4pg/ml, p0.005). No significant 24h variation of serum IL-6 in severe OSAS patients was found before CPAP; however, a significant 24h variation of serum IL-6 was found after CPAP. Intermittent hypoxia during sleep may contribute to systemic inflammation and result in an elevation of serum IL-6 in severe OSAS patients.