Perinatal risk factors for ischemic heart disease - Disentangling the roles of birth weight and preterm birth
Perinatal risk factors for ischemic heart disease - Disentangling the roles of birth weight and preterm birth
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DOI：
10.1161/circulationaha.107.710715
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发表时间：
2008-01-22
期刊：
影响因子：
37.8
通讯作者：
Ekbom, Anders
中科院分区：
文献类型：
--
作者：
Kaijser, Magnus;Bonamy, Anna-Karin Edstedt;Ekbom, Anders
背景——几项研究报告了低出生体重与缺血性心脏病之间的关联，但尚不清楚这种关联是否是通过胎儿生长不良或妊娠持续时间短介导的。方法和结果——在一项队列研究中，我们确定了 1925 年至 1949 年瑞典 4 个主要分娩单位中所有早产或低出生体重的受试者。为了进行比较，在同一来源人群中确定了相同数量的不具备这些标准的受试者。研究人群由 6425 名受试者组成，其中 2931 名受试者出生于妊娠 37 周之前，2176 名受试者出生体重 < 2500 克。通过出生体重与胎龄来估计胎儿生长情况。 1987 年至 2002 年期间，通过全国医院出院和死因登记处对该队列进行了缺血性心脏病发生情况的随访。在该队列中，发生了 617 例缺血性心脏病。与胎儿正常生长的受试者相比，出生时小于胎龄（出生体重）的受试者
Background-Several studies have reported an association between low birth weight and ischemic heart disease, but it remains unclear whether the association is mediated through poor fetal growth or short gestational duration.Methods and Results-In a cohort study, we have identified all subjects born preterm or with a low birth weight at 4 major delivery units in Sweden from 1925 through 1949. For comparison, an equal number of subjects with none of these criteria were identified within the same source population. The study population consists of 6425 subjects, of whom 2931 were born before 37 weeks of gestation and 2176 had a birth weight < 2500 g. Fetal growth was estimated through birth weight for gestational age. The cohort was followed up for occurrence of ischemic heart disease through the nationwide Hospital Discharge and Cause of Death Registries during the period of 1987 through 2002. In the cohort, 617 cases of ischemic heart disease occurred. Compared with subjects with a normal fetal growth, those born small for gestational age (birth weight