The hijacking of cellular signaling and the diabetes epidemic: mechanisms of environmental disruption of insulin action and glucose homeostasis.
The hijacking of cellular signaling and the diabetes epidemic: mechanisms of environmental disruption of insulin action and glucose homeostasis.
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DOI：
10.4093/dmj.2014.38.1.13
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发表时间：
2014-02
影响因子：
5.9
通讯作者：
Sargis RM
中科院分区：
文献类型：
--
作者：
Sargis RM
代谢性疾病的迅速流行导致显著的社会和个人发病率，并威胁到地球仪周围卫生保健系统的稳定。努力了解导致代谢紊乱的因素对于扭转这些令人不安的趋势至关重要。虽然过度的热量消耗和缺乏身体活动加上易感的遗传背景是这一危机的主要驱动因素，但这些因素本身并不能完全解释代谢性疾病在世界范围内流行率增加的幅度和速度。最近的流行病学证据表明，内分泌干扰物与代谢性疾病的发病机制有关。这些化合物代表了人类在成年期和发育期间通过多种途径接触的各种化学物质。此外，越来越多的基于动物和细胞的研究提供了临床前证据，支持环境污染物有助于代谢疾病（包括糖尿病）发展的假设。本文综述了将特定内分泌干扰物与葡萄糖稳态受损联系起来的研究，以及将这些化合物与胰岛素分泌紊乱和胰岛素信号转导受损联系起来的研究。虽然数据仍然有些不完整，但目前的证据支持这样一种假设，即我们的化学污染环境可能在当前的代谢危机中发挥了作用。
The burgeoning epidemic of metabolic disease causes significant societal and individual morbidity and threatens the stability of health care systems around the globe. Efforts to understand the factors that contribute to metabolic derangements are critical for reversing these troubling trends. While excess caloric consumption and physical inactivity superimposed on a susceptible genetic background are central drivers of this crisis, these factors alone fail to fully account for the magnitude and rapidity with which metabolic diseases have increased in prevalence worldwide. Recent epidemiological evidence implicates endocrine disrupting chemicals in the pathogenesis of metabolic diseases. These compounds represent a diverse array of chemicals to which humans are exposed via multiple routes in adulthood and during development. Furthermore, a growing ensemble of animal- and cell-based studies provides preclinical evidence supporting the hypothesis that environmental contaminants contribute to the development of metabolic diseases, including diabetes. Herein are reviewed studies linking specific endocrine disruptors to impairments in glucose homeostasis as well as tying these compounds to disturbances in insulin secretion and impairments in insulin signal transduction. While the data remains somewhat incomplete, the current body of evidence supports the hypothesis that our chemically polluted environment may play a contributing role in the current metabolic crisis.