Nitrous oxide suppresses the electromyographic response evoked by electrical stimulation of the motor cortex.
Nitrous oxide suppresses the electromyographic response evoked by electrical stimulation of the motor cortex.
复制标题
一氧化二氮抑制运动皮层电刺激引起的肌电反应。
DOI：
10.1227/00006123-198901000-00009
复制
发表时间：
1989
期刊：
影响因子：
4.8
通讯作者：
A. Ebner
中科院分区：
文献类型：
--
作者：
J. Zentner;A. Ebner
研究了氧化亚氮对大鼠皮层电刺激和颈中电刺激引起的运动诱发电位（MEP）的影响，并与刺激胫后神经后体感诱发电位（SEP）的早期成分进行了比较。我们发现一氧化二氮逐渐抑制MEP，这取决于吸入剂的浓度。当氧化亚氮浓度为66 vol%时，MEP完全消失，而SEP的初始组分N1-P1仅略有降低。我们得出结论，电刺激皮质脊髓束引起的下行冲动主要在脊髓神经元或神经元间系统水平受到抑制，因为(1)神经肌肉传递不会被氧化亚氮阻断，(2)MEP抑制与皮质和颈中刺激相同。
The influence of nitrous oxide on motor evoked potential (MEP) elicited in rats by cortical and midcervical electrical stimulation was studied and compared with early components of somatosensory evoked potential (SEP) following stimulation of the posterior tibial nerve in 6 rats. We found that nitrous oxide gradually suppresses MEP, depending on the concentration of this inhalation agent. At a concentration of 66 vol% of nitrous oxide, the MEP was completely abolished, whereas the initial component N1-P1 of the SEP was only slightly reduced. We conclude that the descending impulse elicited by electrical stimulation of the corticospinal tract is mainly inhibited at the level of the spinal neuronal or interneuronal system, since (1) neuromuscular transmission is not blocked by nitrous oxide, and (2) MEP suppression is the same following cortical and midcervical stimulation.