Passive vibration on the legs reduces peripheral and systemic arterial stiffness
Passive vibration on the legs reduces peripheral and systemic arterial stiffness
复制标题
腿部被动振动可减少外周和全身动脉僵硬度
DOI：
10.1038/hr.2011.164
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发表时间：
2012
影响因子：
5.4
通讯作者：
A. Figueroa
中科院分区：
文献类型：
--
作者：
A. Wong;M. Sanchez;Ryan Gil;F. Vicil;Song;A. Figueroa
间歇性腿部运动（101分钟组）和全身振动（WBV）可降低臂踝脉搏波速度（baPWV）1和腿部PWV（legPWV），但不会降低主动脉PWV。2由于baPWV是全身动脉僵硬度的指标3，主要受主动脉PWV（B58%）和下肢PWV（B23%）的影响，4先前发表的结果1，2表明WBV通过外周而不是中心PWV影响baPWV。运动后PWV降低与运动肢体的血管舒张有关。5，6同样，间歇性WBV（33分钟组）7或被动振动（PV）8已被证明在振动后仅1分钟即可增加振动肢体的血流量。有趣的是，10分钟的连续PV被发现在振动后5分钟增加手臂皮肤血流量，9表明暴露持续时间和血管舒张之间有直接关系。我们假设腿部PV可能比主动脉PWV更能降低legPWV和baPWV。本研究的目的是检查长时间连续肺静脉后的PWV反应。共有23例（男性10例，女性13例）健康（年龄23±3岁，身高21。67±0.02米，重1/4 67。3±3.5 kg）的受试者提供了他们的书面同意书，并得到了机构审查委员会的批准。无振动对照（CON）和PV阶段随机化，间隔48- 72小时。受试者在测试前以仰卧位休息，大腿和小腿在振动平台（Powerplate，Badhoevedorp，The Netherlands）上20分钟，CON或PV 10分钟，恢复30分钟。他们的腿直接暴露于频率（25 Hz）和振幅（2 mm）的连续振动，提供B5的加速度。37 G的研究结果显示，在总持续时间和/或强度相似的间歇或连续振动后，血流增加8，10或baPWV 1和legPWV 2降低。（VP-2000，Omron Healthcare，弗农山庄，IL，美国），其在双臂周围使用BP袖带（肱动脉）和踝（胫后动脉）上测量血压，并在右颈动脉和股动脉上测量血压计，以获得baPWV、主动脉PWV（颈动脉-股动脉）和legPWV（股动脉-踝）。将脉搏波的脚与心电图的R波相关联以计算通过时间。主动脉PWV的采样点之间的距离是用非弹性胶带测量的，而baPWV和legPWV的采样点之间的距离是根据受试者的身高计算的。图3胸骨上切迹至肱动脉、股动脉和胫动脉以及股动脉至胫动脉的路径长度
Intermittent leg exercise (10Â1-min sets) with whole-body vibration (WBV) decreases brachial-ankle pulse-wave velocity (baPWV) 1 and leg PWV (legPWV) but not aortic PWV. 2 As baPWV is an index of systemic arterial stiffness 3 mainly influenced by aortic PWV (B58%) and legPWV (B23%), 4 previously published results 1, 2 suggest that WBV affects baPWV through peripheral but not central PWV. The post-exercise decrease in PWV is associated with vasodilation in the exercised limb. 5, 6 Similarly, intermittent WBV (3Â3-min sets) 7 or passive vibration (PV) 8 has been shown to increase blood flow in the vibrated limb after only 1-min post vibration. Interestingly, 10 min of continuous PV was found to increase arm skin blood flow after 5-min post vibration, 9 indicating a direct relationship between the duration of exposure and vasorelaxation. We hypothesized that PV on the legs may decrease legPWV and baPWV more than aortic PWV. The purpose of our study was to examine PWV responses following continuous PV of lengthy duration. A total of 23 (M¼10 and F¼13) healthy (age¼23±3 years, height¼1. 67±0.02 m and weight¼67. 3±3.5 kg) subjects provided their written consent, which was approved by the Institutional Review Board. The no-vibration control (CON) and PV sessions were randomized and separated by 48–72h. Subjects rested in the supine position with their thighs and calves over the vibration platform (Powerplate, Badhoevedorp, The Netherlands) for 20min before testing, 10min of CON or PV, and 30min of recovery. Their legs were directly exposed to continuous vibration at a frequency (25Hz) and amplitude (2 mm) that provided an acceleration of B5. 37G based on studies showing increased blood flow 8, 10 or decreased baPWV 1 and legPWV 2 following intermittent or continuous vibration of similar total duration and/or intensity.PWV and brachial blood pressure (BP) were measured in duplicate with an automatic device (VP-2000, Omron Healthcare, Vernon Hills, IL, USA), which uses BP cuffs around both arms (brachial artery), and ankles (posterior-tibial artery) and tonometers over the right carotid and femoral arteries to obtain baPWV, aortic PWV (carotid-femoral) and legPWV (femoral-ankle). The feet of the pulse waves were related to the ECG’s R-wave to calculate transit time. The distance between sampling points for aortic PWV was measured with a non-elastic tape, whereas for baPWV and legPWV, this value was calculated according to the subject’s height. 3 Path lengths from the suprasternal notch to the brachial, femoral and tibial arteries, and from the femoral to the tibial