Immunity in equine cyathostome infections
Immunity in equine cyathostome infections
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DOI：
10.1016/s0304-4017(99)00093-x
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发表时间：
1999-08-31
影响因子：
2.6
通讯作者：
Chapman, MR
中科院分区：
文献类型：
--
作者：
Klei, TR;Chapman, MR
明确马cathostome感染的免疫和免疫反应的特点是很重要的，以推进我们的理解，这些线虫在主机内的发展，归因于他们的临床条件，并在制定更合理的和新的战略，他们的控制。尽管如此，目前对这一主题知之甚少。目前的数据的基础上，实地观察，蠕虫的负担和粪便卵计数表明，马获得一个抵抗cyathostome感染与年龄。这种反应是缓慢发展和不完全的，因为大多数马，无论年龄，都有大量的这些线虫。从实验感染中获得了更令人信服的证据，表明先前暴露于感染的成熟马对再次感染具有抗性，并且这种抗性针对寄生虫生命周期的所有阶段。此外，对粘膜内发育阶段的一些免疫似乎需要较少的暴露，并且发生在较年轻的动物中。一些非特异性的事件，诱导驱逐所有种类的内腔居住线虫似乎也发生后感染L3。在针对成虫蠕虫提取物的有限研究中检测到了抗体。毫不奇怪，这些抗体的滴度与再感染的抗性无关。然而，偶然观察到IL-4基因的更高表达与腔内寄生虫的自发排出相关。需要开发一个可用的模型，以进一步提高我们在这一领域的知识。(C)1999 Elsevier Science B. V.保留所有权利。
Defining the characteristics of immunity and immune responses to equine cyathostome infections is clearly important to advancing our understanding of the development of these nematodes within the host, the clinical conditions attributed to them, and in developing more rational and novel strategies for their control. Nonetheless, little is currently known on this topic. Current data based on field observations, worm burdens and fecal egg counts suggest that horses acquire a resistance to cyathostome infection with age. This response is slow to develop and incomplete in that most horses regardless of age harbor significant populations of these nematodes. More convincing evidence has been obtained from experimental infections which indicate that mature horses previously exposed to infection are resistant to re-infection and this resistance is directed at all stages of the parasite life cycle. Further, some immunity against the developing stages within the mucosa appears to require less exposure and occurs in younger animals. Some non-specific events which induce expulsion of all species of lumenal dwelling nematodes also appear to take place post-infection with L3. Antibodies have been detected in Limited studies against somatic extracts of adult worms. Not surprisingly, titers of these antibodies do not correlate resistance to re-infection. Serendipitous observations have, however, associated a greater expression of the gene for IL-4 with the spontaneous expulsion of lumenal parasites. The development of a usable model is required to further advance our knowledge in this area. (C) 1999 Elsevier Science B.V. All rights reserved.