Evidence for an important role of host microRNAs in regulating hepatic fibrosis in humans infected with &ITSchistosoma japonicum&IT
Evidence for an important role of host microRNAs in regulating hepatic fibrosis in humans infected with &ITSchistosoma japonicum&IT
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DOI：
10.1016/j.ijpara.2017.05.007
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发表时间：
2017-11-01
影响因子：
4
通讯作者：
Dessein, Alain
中科院分区：
文献类型：
--
作者：
Cabantous, Sandrine;Hou, Xunya;Dessein, Alain
MicroRNAs(MiRNAs)是一种短的、非编码的RNA，可以抑制靶基因转录本的翻译。它们参与了细胞的增殖、存活、分化、迁移和代谢等多种活动。我们在这里报告了第一个已知的人类肝脏的miRNome和转录组分析，显示了由于日本血吸虫感染而导致的晚期纤维化。我们提出的证据表明，hsa-miR-150-5p、hsa-miR-10a-5p、hsa-miR-199a-3p、hsa-miR-4521、hsa-miR-222/221、hsa-miR-663b和hsa-miR-143-3p(未校正)通过作用于代谢、细胞外基质蛋白的组织、脂质动员和限制氧化损伤应激而在肝纤维化中发挥重要作用。(C)2017年澳大利亚寄生虫学学会。爱思唯尔有限公司出版。保留所有权利。
MicroRNAs (miRNAs) are short, non-coding RNAs that repress the translation of target gene transcripts. They have been implicated in various activities such as cell proliferation, survival, differentiation, migration and metabolism. We report here the first known miRNome and transcriptome analysis of human livers displaying advanced fibrosis due to Schistosoma japonicum infection. We present evidence that hsa-miR-150-5p, hsa-miR-10a-5p, hsa-miR-199a-3p, hsa-miR-4521, hsa-miR-222/221, hsa-miR-663b and hsa-miR-143-3p (associated without correction) play an important role in hepatic fibrosis by acting on metabolism, organization of the extracellular matrix proteins, lipid mobilization and limitation of oxidative damage stress. (C) 2017 Australian Society for Parasitology. Published by Elsevier Ltd. All rights reserved.