Reward-period activity in primate dorsolateral prefrontal and orbitofrontal neurons is affected by reward schedules
Reward-period activity in primate dorsolateral prefrontal and orbitofrontal neurons is affected by reward schedules
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DOI：
10.1162/089892906775783679
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发表时间：
2006-02-01
影响因子：
3.2
通讯作者：
Funahashi, S
中科院分区：
文献类型：
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作者：
Ichihara-Takeda, S;Funahashi, S
在背外侧前额叶皮层（DLPFC）和眶额皮层（OFC）中观察到的奖励期活动被认为代表了奖励传递的检测。为了研究这种活动在这些区域中是否起着相同的作用，我们在不同的奖励时间表下检查了这种活动，以及奖励时间表是否对这些区域中的每一个区域的这种活动都有类似的影响。一只猴子在两种奖励时间表下完成了眼动延迟反应（ODR）任务。在ODR-1时间表中，猴子只有在四次成功的试验后才获得大量奖励，而在ODR-2时间表中，它在每次成功的试验后都会获得少量奖励。虽然在这两个区域都观察到了奖赏期活动，但更多的神经元在OFC中表现出这种活动。奖励期活动调制的接近奖励交付在这两个领域，这一功能更频繁地观察到的眶额皮层。这种活动的开始时间也逐渐提前取决于奖励交付的接近程度。此外，许多具有这种活动的OFC神经元对免费奖励的传递做出了反应。这些结果表明，在OFC的奖励期活动表示检测的奖励交付和该活动的幅度和开始时间的逐渐变化表示的期望的奖励交付。在DLPFC神经元中观察到奖励期活动的类似特征，尽管大量的DLPFC神经元对自由奖励传递没有反应，并且在该活动的起始时间没有观察到任何进展。这些结果表明，奖励期活动在DLPFC参与是否正确的性能实现。因此，虽然在这两个领域观察到类似的奖励期活动，在OFC的活动表示检测奖励交付和猴子的动机状态的影响，而在DLPFC似乎参与监测是否达到必要的性能。
Reward-period activity observed in the dorsolateral prefrontal cortex ( DLPFC) and the orbitofrontal cortex ( OFC) is thought to represent the detection of reward delivery. To investigate whether this activity plays the same role in these areas, we examined this activity under different reward schedules and whether the reward schedule has similar effects on this activity in each of these areas. A monkey performed an oculomotor delayed-response ( ODR) task under two reward schedules. In the ODR-1 schedule, the monkey received a large amount of reward only after four successful trials, whereas in the ODR-2 schedule, it received a small amount of reward after every successful trial. Although reward-period activity was observed in both areas, more neurons exhibited this activity in the OFC. Reward-period activity was modulated by the proximity to reward delivery in both areas and this feature was observed more frequently in the OFC. The onset time of this activity also gradually advanced depending on the proximity to reward delivery. Moreover, many OFC neurons with this activity responded to free reward delivery. These results indicate that reward-period activity in the OFC represents the detection of reward delivery and that the gradual change in the magnitude and the onset time of this activity represents the expectation of reward delivery. Similar features of reward-period activity were observed in DLPFC neurons, although a significant number of DLPFC neurons did not respond to free reward delivery and no advance was observed in the onset time of this activity. These results suggest that reward-period activity in the DLPFC participates in whether or not correct performance was achieved. Thus, although similar reward-period activity was observed in both areas, the activity in the OFC represents the detection of reward delivery and is affected by the monkey's motivational state, whereas that in the DLPFC seems to participate in monitoring whether or not the necessary performance is achieved.