1,25-DIHYDROXYVITAMIN D3 RECEPTORS IN HUMAN-LEUKOCYTES
1,25-DIHYDROXYVITAMIN D3 RECEPTORS IN HUMAN-LEUKOCYTES
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DOI：
10.1126/science.6310748
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发表时间：
1983-01-01
期刊：
影响因子：
56.9
通讯作者：
MANOLAGAS, SC
中科院分区：
文献类型：
--
作者：
PROVVEDINI, DM;TSOUKAS, CD;MANOLAGAS, SC
在正常人外周血单核白细胞中检测到1，25-二羟维生素D3受体。这种大分子存在于单核细胞中，但不存在于正常静息的外周B和T淋巴细胞中。它存在于已建立的恶性B、T和非B、非T人淋巴细胞系中，以及从正常人获得并在体外活化的T和B淋巴细胞中。
A 1,25-dihydroxyvitamin D3 receptor was detected in peripheral mononuclear leukocytes from normal humans. This macromolecule was present in monocytes but absent from normal resting peripheral B and T lymphyocytes. It was present in established lines of malignant B, T, and non-B, non-T human lymphocytes, as well as in T and B lymphocytes obtained from normal humans and activated in vitro.