Comparative profile for COVID-19 cases from China and North America: Clinical symptoms, comorbidities and disease biomarkers.
Comparative profile for COVID-19 cases from China and North America: Clinical symptoms, comorbidities and disease biomarkers.
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DOI：
10.12998/wjcc.v9.i1.118
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发表时间：
2021-01-06
影响因子：
1.1
通讯作者：
Vasileva D
中科院分区：
文献类型：
--
作者：
Badawi A;Vasileva D
已经注意到严重急性呼吸综合征冠状病毒2或2019冠状病毒病（COVID-19）的易感性和结局存在很大的个体间和人群间差异。了解这些差异以及它们如何影响感染的脆弱性和疾病的严重程度，对于公共卫生干预至关重要。 分析和比较中国和北美这两个在许多与疾病风险相关的环境、宿主和医疗保健因素方面存在差异的地区的COVID-19病例概况。我们进行了一项荟萃分析，以检查和比较来自中国（105项研究）和北美（19项研究）的临床研究和数据的COVID-19病例的人口统计学信息、临床症状、合并症、疾病严重程度和疾病生物标志物水平。 来自北美的COVID-19患者比中国患者年龄更大，男女比例更高。发热、咳嗽、疲劳和呼吸困难是两个研究地区最常见的临床症状（在两个地区约30%至75%的病例中存在）。对COVID-19患者合并症（如肥胖、高血压、糖尿病、心血管疾病、慢性阻塞性肺病、癌症和慢性肾脏疾病）患病率的荟萃分析显示，与中国相比，北美患者的患病率显著更高。合并症与年龄呈正相关，但与北美相比，中国的年龄范围明显更小。最常见的感染结局是急性呼吸窘迫综合征，在北美的发生率是中国的2倍。北美病例的C反应蛋白水平是中国病例的4.5倍。来自中国和北美的COVID-19病例特征的差异可能与两个地区之间的环境、宿主和医疗保健相关因素的差异有关。这种人群间的差异--以及人群内的变异性--强调了描述卫生不公平和不平等对公共卫生应对COVID-19的影响的必要性，并有助于为疫情的重新出现做好准备。
Large inter-individual and inter-population differences in the susceptibility to and outcome of severe acute respiratory syndrome coronavirus 2 or coronavirus disease 2019 (COVID-19) have been noted. Understanding these differences and how they influence vulnerability to infection and disease severity is critical to public health intervention. To analyze and compare the profile of COVID-19 cases between China and North America as two regions that differ in many environmental, host and healthcare factors related to disease risk. We conducted a meta-analysis to examine and compare demographic information, clinical symptoms, comorbidities, disease severity and levels of disease biomarkers of COVID-19 cases from clinical studies and data from China (105 studies) and North America (19 studies). COVID-19 patients from North America were older than their Chinese counterparts and with higher male: Female ratio. Fever, cough, fatigue and dyspnea were the most common clinical symptoms in both study regions (present in about 30% to 75% of the cases in both regions). Meta-analysis for the prevalence of comorbidities (such as obesity, hypertension, diabetes, cardiovascular diseases, chronic obstructive pulmonary disease, cancer, and chronic kidney diseases) in COVID-19 patients were all significantly more prevalent in North America compared to China. Comorbidities were positively correlated with age but at a significantly younger age range in China compared to North American. The most prevalent infection outcome was acute respiratory distress syndrome which was 2-fold more frequent in North America than in China. Levels of C-reactive protein were 4.5-fold higher in the North American cases than in cases from China. The differences in the profile of COVID-19 cases from China and North America may relate to differences in environmental-, host- and healthcare-related factors between the two regions. Such inter-population differences-together with intra-population variability-underline the need to characterize the effect of health inequities and inequalities on public health response to COVID-19 and can assist in preparing for the re-emergence of the epidemic.
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影响因子：
4.5
作者：
de la Rica, Roberto;Borges, Marcio;Gonzalez-Freire, Marta
通讯作者：
Gonzalez-Freire, Marta
DOI：
10.1126/science.1262110
发表时间：
2015-05-08
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
GTEx Consortium
通讯作者：
GTEx Consortium
影响因子：
56.3
作者：
Dooley, Kelly E.;Chaisson, Richard E.
通讯作者：
Chaisson, Richard E.
影响因子：
15.9
作者：
Chen, Guang;Wu, Di;Ning, Qin
通讯作者：
Ning, Qin
影响因子：
2
作者：
Campbell, Ian
通讯作者：
Campbell, Ian