ISOFLURANE EFFECTS IN RAT HIPPOCAMPAL CORTEX - A QUANTITATIVE-EVALUATION OF DIFFERENT CELLULAR SITES OF ACTION
ISOFLURANE EFFECTS IN RAT HIPPOCAMPAL CORTEX - A QUANTITATIVE-EVALUATION OF DIFFERENT CELLULAR SITES OF ACTION
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DOI：
10.1111/j.1748-1716.1986.tb08019.x
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发表时间：
1986-12-01
期刊：
影响因子：
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通讯作者：
LANGMOEN, IA
中科院分区：
文献类型：
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作者：
BERGJOHNSEN, J;LANGMOEN, IA
为了定量评价吸入麻醉剂对中枢神经系统神经元兴奋性和突触传递的影响，我们研究了异氟烷对大鼠海马皮质切片的作用。1.5%异氟烷（1.38%麻醉50%的试验大鼠（MAC））使锥体细胞的顺向诱发活动减少62%。这是由于对传入纤维、兴奋性突触和锥体细胞的综合作用。对突触后神经元的影响几乎与对兴奋性突触的影响一样强：由给定突触电流引起的群体尖峰降低了24%，响应于给定传入纤维齐射的场EPSP降低了27%。突触前纤维的齐射减少了17%。
In order to evaluate quantitatively the effects of an inhalation anaesthetic on neuronal excitability and on synaptic transmission in the central nervous system, we have examined the action of isoflurane on slices from rat hippocampal cortex. Isoflurane 1.5 % (1.38 % anaesthetize 50 % of tested rats (MAC)) reduced orthodromically evoked activity in pyramidal cells by 62%. This was due to the combined effects on afferent fibres, excitatory synapses and pyramidal cells. The effect on the postsynaptic neurones was almost as strong as the effect on the excitatory synapses: the population spike evoked by a given synaptic current was reduced by 24%, and the field‐EPSP in response to a given afferent fibre volley by 27%. The presynaptic fibre volley was reduced by 17%.