Maternal communication with gametes and embryos
Maternal communication with gametes and embryos
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DOI：
10.1016/j.theriogenology.2008.06.010
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发表时间：
2008-11-01
期刊：
影响因子：
2.8
通讯作者：
Fazeli, A.
中科院分区：
文献类型：
--
作者：
Fazeli, A.
配子和胚胎与其母体环境相互作用的机制对于牲畜和人类的繁殖成功至关重要。长程（激素）和短程信号分子在介导细胞与细胞母体相互作用/与配子和胚胎的通讯中发挥重要作用。破坏这种相互作用的轻微故障或环境干扰可能会阻碍胚胎发育。这可能会导致胚胎产生记忆，从而导致后代在成年后容易患退行性疾病。尽管有大量的研究和文献，但并非所有涉及的信号分子及其相互关系都是已知的。高通量基因组和质子组分析工具（例如微阵列和定量蛋白质组技术）的应用进展对我们对母体与配子和胚胎沟通的各个方面的理解产生了积极影响。最近的进展表明，女性生殖道中存在一种局部机制，能够识别配子和胚胎的到达，并为下一阶段相应地调节生殖道的环境。进一步的投资正在进行中，以描述该系统的细节。重要的是要考虑母体与配子和胚胎交流的空间或时间成分，这可能会对发育潜力产生影响。最后，应用系统生物学方法来创建母体与配子和胚胎通讯的相互作用图谱似乎是至关重要的，并且为与工程师和数学建模者的跨学科合作提供了绝佳的机会。 (C) 2008 Elsevier Inc. 保留所有权利。
Mechanisms for gametes and embryos to interact with their maternal environment are crucial in achieving reproductive success, both in livestock and the human. Long-range (hormones) and short-range signalling molecules play important roles in mediating cell-cell maternal interactions/communications with gametes and embryos. Slight malfunctions or disturbances of the environment that hsot this interaction can retard embryonic development. This may lead to creation of a memory for the embryo leading to offspring prone to degenerative diseases in adulthood. Despite an overwhelming amount of researh and the literature, not all signalling molecules involved and their relationship with each other are known. Progress in the application of high-throughput genomic and protomic analytical tools, such as microarrays and quantative proteomic technologies has had a positive impact on our understanding of various aspects of maternal communication with gametes and embryos. Recent advances point to the presence of a local mechanism in the female reproductive tract capable of recognising the arriva of gametes and embryos and modulating the tract's environment accordingly for the next stage. Further investations are underway to characterise the details of this system. It is important to consider spatial or temproal components of maternal communication with gametes and embryos that may confer consequences for developmental potential. Finally, it seems that the application of a systems biology approach for creation of an interactome map of maternal communication with gametes and embryos is essential and provides an excellent opportunity for an inter-discplinary collaboration with engineers and amthematical modellers. (C) 2008 Elsevier Inc. All rights reserved.