Synthesis of 3-substituted 1,5-aldehyde esters via an organocatalytic highly enantioselective conjugate addition of new carbonylmethyl 2-pyridinylsulfone to enals.
Synthesis of 3-substituted 1,5-aldehyde esters via an organocatalytic highly enantioselective conjugate addition of new carbonylmethyl 2-pyridinylsulfone to enals.
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DOI：
10.1039/c1cc15714k
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发表时间：
2012-01
影响因子：
4.9
通讯作者：
Jing Deng;Fei Wang;Wenzhong Yan;Jin Zhu;Hualiang Jiang;Wei Wang;Jian Li
中科院分区：
文献类型：
--
作者：
Jing Deng;Fei Wang;Wenzhong Yan;Jin Zhu;Hualiang Jiang;Wei Wang;Jian Li
发展了一种高对映选择性的有机催化剂，用于新的亲核羰基甲基2-吡啶基砜与烯醛的共轭加成反应，产率高，对映选择性高。所得迈克尔加成物是多种有机转化的通用构件。
A highly enantioselective organocatalytic protocol for conjugate addition of new nucleophilic carbonylmethyl 2-pyridinylsulfone to enals has been developed in good yields and with high enantioselectivities. The resulting Michael adducts are versatile building blocks for a variety of organic transformations.