HUMAN ONTOGENY .3. CELL-DEATH IN FETAL MUSCLE
HUMAN ONTOGENY .3. CELL-DEATH IN FETAL MUSCLE
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DOI：
10.1007/bf00310140
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发表时间：
1991-01-01
影响因子：
12.7
通讯作者：
GOEBEL, HH
中科院分区：
文献类型：
--
作者：
FIDZIANSKA, A;GOEBEL, HH
研究了正常人类胎儿肌肉中自然发生的肌肉细胞死亡，以确定肌肉成熟的时间和结构差异。在发育中的肌肉中发现了两种类型的退行性改变：细胞质和细胞核。妊娠10 - 16周时，原代肌管和成熟肌管的变性导致细胞质凝聚和破坏，线粒体肿胀和肌浆网扩张。相反，未成熟肌纤维的形成与卫星肌纤维的解体有关，其特征是核退行性改变。这些发现表明，自然发生的肌肉细胞死亡表现为细胞坏死的两个连续阶段的现象。最初，在肌管阶段，一些肌肉细胞被消除。在后期，单个细胞从似乎决定肌纤维最终形状和大小的细胞群中移除。
Naturally occurring muscle cell death in normal human fetal muscle was examined to determine the timing and structural differences with respect to muscle maturity. Two types of degenerative changes in developing muscle were found: cytoplasmic and nuclear. Degeneration of the primary and mature myotubes between 10 and 16 weeks of gestation entailed cytoplasmic condensation and disruption, swelling of mitochondria and dilatation of sarcoplasmic reticulum. In contrast, the formation of immature muscle fibres was associated with disintegration of satellite myofibres characterized by nuclear degenerative changes. These findings indicate that naturally occurring muscle cell death appears as a two-successive-stage phenomenon of cell necrosis. Initially, at the myotube stage, a number of muscle cells are eliminated. In the later stage a single cell is removed from the cluster which seemingly is responsible for final shape and size of the muscle fibre.