Teratogen update: gestational effects of maternal hyperthermia due to febrile illnesses and resultant patterns of defects in humans.
Teratogen update: gestational effects of maternal hyperthermia due to febrile illnesses and resultant patterns of defects in humans.
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DOI：
10.1002/(sici)1096-9926(199811)58:5
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发表时间：
1998-11
期刊：
影响因子：
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通讯作者：
J. Graham;M. Edwards;M. Edwards
中科院分区：
文献类型：
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作者：
J. Graham;M. Edwards;M. Edwards
本文综述了高温对人体和实验动物致畸作用的相关文献。这是最初在动物中发现的第一种致畸剂，随后发现在人类中观察到类似的缺陷模式时引起关注。热疗是一种具有流产和畸形的剂量-反应曲线的物理剂，但在某些情况下，这些影响可以通过热休克反应（HSR）来减轻。我们已经回顾了HSR的已知功能，并提供了一些见解，为什么胚胎在初始剂量的热后有一些保护，如果它足以启动反应。因此，通过回顾高温对实验动物的影响，以及致畸的畸形和保护机制，我们试图了解人类高温致畸的影响。
This review has covered the pertinent literature concerning the teratogenic effects of hyperthermia in man and experimental animals. This is the first teratogen that was initially discovered in animals and then subsequently found to be a cause for concern in humans when similar patterns of defects were observed. Hyperthermia is a physical agent with a dose-response curve for abortions and malformations, but these effects can be mitigated in some circumstances by the heat shock response (HSR). We have reviewed the known functions of HSR and provided some insight into why embryos have some protection following an initial dose of heat, if it is sufficient to initiate the response. Thus, by reviewing the effects of hyperthermia in experimental animals, as well as malformative and protective mechanisms of teratogenesis, we have attempted to understand the effects of human hyperthermia teratogenesis.