Incidence, case fatality, and functional outcome of intracerebral haemorrhage overtime, according to age, sex, and ethnic origin: a systematic review and meta-analysis
Incidence, case fatality, and functional outcome of intracerebral haemorrhage overtime, according to age, sex, and ethnic origin: a systematic review and meta-analysis
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DOI：
10.1016/s1474-4422(09)70340-0
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发表时间：
2010-02-01
期刊：
影响因子：
48
通讯作者：
Klijn, Catharina J. M.
中科院分区：
文献类型：
--
作者：
van Asch, Charlotte J. J.;Luitse, Merel J. A.;Klijn, Catharina J. M.
背景自20世纪80年代初以来，成像技术已使基于人群的。脑出血的研究。我们的目的是评估自1980年以来发表的研究中脑出血的发病率、病死率和功能结局与年龄、性别、种族和时间段的关系。方法从PubMed和Embase检索预定义的纳入标准，我们确定了1980年1月至2008年11月发表的基于人群的研究。我们计算了发病率和病死率。在随机效应二项式荟萃分析中汇总了多项研究的发生率。病死率的时间趋势进行了评估与加权线性回归analysis.Findings 36个合格的研究描述了44个时间段（年中范围1983-2006）。这些研究包括8145例脑出血患者。1980年至2008年期间发病率没有下降。总体发生率为24.6/100000人-年（95% CI 19.7-30.7）。女性的发生率并不显著低于男性（总体发生率比0.85，95% CI 0.61-1.18）。使用45-54岁年龄组作为参考，发病率从45岁以下人群的0.10（95% CI 0.06-0.14）增加到85岁以上人群的9.6（6.6-13.9）。1个月时的中位病死率为40.4%（范围13.1-61.0），未随时间降低，日本（16.7%，95% CI 15.0-18.5）低于其他地区（42.3%，40.9-43.6）。6项研究报告了功能结局，独立率在12%至39%之间。每10万人-年的脑出血发生率为24.2（95% CI 20.9-28.0）在白色人群中，22.9（14.8-35.6）黑人，19.6（15.7-24.5）西班牙裔人，亚洲人为51.8（38.8-69.3）。解释脑出血的发病率随着年龄的增长而增加，并且在1980年至2006年期间没有下降。日本的病死率低于其他地方，随着年龄的增长而增加，并且没有随着时间的推移而下降。需要更多关于功能结局的数据。
Background Since the early 1980s, imaging techniques have enabled population-based. studies of intracerebral haemorrhage. We aimed to assess the incidence, case fatality, and functional outcome of intracerebral haemorrhage in relation to age, sex, ethnic origin, and time period in studies published since 1980.Methods From PubMed and Embase searches with predefined inclusion criteria, we identified population-based studies published between January, 1980, and November, 2008. We calculated incidence and case fatality. Incidences for multiple studies were pooled in a random-effects binomial meta-analysis. Time trends of case fatality were assessed with weighted linear-regression analysis.Findings 36 eligible studies described 44 time periods (mid-year range 1983-2006). These studies included 8145 patients with intracerebral haemorrhage. Incidence did not decrease between 1980 and 2008. Overall incidence was 24.6 per 100000 person-years (95% CI 19.7-30.7). Incidence was not significantly lower in women than in men (overall incidence ratio 0.85, 95% CI 0.61-1.18). Using the age group 45-54 years as reference, incidence ratios increased from 0.10 (95% CI 0.06-0.14) for people aged less than 45 years to 9.6 (6.6-13.9) for people older than 85 years. Median case fatality at 1 month was 40.4% (range 13.1-61.0) and did not decrease over time, and was lower in Japan (16.7%, 95% CI 15.0-18.5) than elsewhere (42.3%, 40.9-43.6). Six studies reported functional outcome, with independency rates of between 12% and 39%. Incidence of intracerebral haemorrhage per 100 000 person-years was 24.2 (95% CI 20.9-28.0) in white people, 22.9 (14.8-35.6) in black people, 19.6 (15.7-24.5) in Hispanic people, and 51.8 (38.8-69.3) in Asian people.Interpretation Incidence of intracerebral haemorrhage increases with age and has not decreased between 1980 and 2006. Case fatality is lower in Japan than elsewhere, increases with age, and has not decreased over time. More data on functional outcome are needed.