Total synthesis of xanthanolides
Total synthesis of xanthanolides
复制标题
DOI：
10.1016/j.tet.2010.08.061
复制
发表时间：
2010-10-23
期刊：
影响因子：
2.1
通讯作者：
Shindo, Mitsuru
中科院分区：
文献类型：
--
作者：
Matsuo, Kazumasa;Ohtsuki, Keiko;Shindo, Mitsuru
以分子内酰化和Wittig内酯化为关键步骤，实现了(+)-和(-)-sundiversifolide的全合成和绝对构型的测定。还制备了黄原内酯倍半萜内酯、8-表黄原 (1)、二氢黄原 (2) 和黄原 (3)，以源自 sundiversifolide 合成的常见中间体为原料。 (C) 2010 Elsevier Ltd. 保留所有权利。
The total synthesis and determination of the absolute configuration of (+)- and (-)-sundiversifolide have been achieved via intramolecular acylation and Wittig-lactonization as the key steps. The xanthanolide sesquiterpene lactones, 8-epi-xanthatin (1), dihydroxanthatin (2), and xanthatin (3) were also prepared, starting from a common intermediate derived from the synthesis of sundiversifolide. (C) 2010 Elsevier Ltd. All rights reserved.