Motor Neurons and the Sense of Place
Motor Neurons and the Sense of Place
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DOI：
10.1016/j.neuron.2011.10.021
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发表时间：
2011-11-03
期刊：
影响因子：
16.2
通讯作者：
Kelly, John S.
中科院分区：
文献类型：
--
作者：
Jessell, Thomas M.;Suermeli, Guelsen;Kelly, John S.
70年前，George Romanes开始记录脊柱运动系统的解剖组织，揭示了一个多层次的地形图，将运动神经元的聚集和稳定位置与肢体肌肉的空间排列和生物力学特征联系起来。到目前为止，这些发现已经为分析神经控制运动提供了结构基础，并为探索指导脊髓运动神经回路连接的机制的研究提供了指导。在这篇简短的文章中，我们概述了Romanes发现的核心，并将它们置于最近的研究背景中，这些研究开始提供对分配运动池位置的分子程序的洞察，并解决运动神经元位置如何塑造电路组装。Romanes的发现揭示了神经元定位如何以及为什么有助于感觉-运动连接，并可能与中枢神经系统其他区域的回路组织有关。
Seventy years ago George Romanes began to document the anatomical organization of the spinal motor system, uncovering a multilayered topographic plan that links the clustering and settling position of motor neurons to the spatial arrangement and biomechanical features of limb muscles. To this day, these findings have provided a structural foundation for analysis of the neural control of movement and serve as a guide for studies to explore mechanisms that direct the wiring of spinal motor circuits. In this brief essay we outline the core of Romanes's findings and place them in the context of recent studies that begin to provide insight into molecular programs that assign motor pool position and to resolve how motor neuron position shapes circuit assembly. Romanes's findings reveal how and why neuronal positioning contributes to sensory-motor connectivity and may have relevance to circuit organization in other regions of the central nervous system.