MiR-608 rs4919510 is associated with prognosis of hepatocellular carcinoma
MiR-608 rs4919510 is associated with prognosis of hepatocellular carcinoma
复制标题
MiR-608 rs4919510与肝细胞癌的预后相关。
DOI：
10.1007/s13277-016-4897-1
复制
发表时间：
2016-07-01
期刊：
影响因子：
--
通讯作者：
Jiang, De-Ke
中科院分区：
文献类型：
--
作者：
Ma, Xiao-Pin;Yu, Guopeng;Jiang, De-Ke
微小RNA（miRNA）内的单核苷酸多态性（SNP）被认为是各种癌症风险和预后的潜在标志物。在目前的研究中，我们的目的是确定miR-608 rs 4919510是否影响肝细胞癌（HCC）的预后。我们使用来自362例接受手术切除HCC肿瘤的HCC患者血液样本的DNA对rs 4919510进行基因分型。使用考克斯比例风险模型估计rs 4919510与总生存期（OS）、人口统计学特征和临床特征之间的关联。结果显示，携带rs 4919510 CC基因型的HCC患者的OS显著长于携带GG基因型的患者（P = 0.013，风险比[HR] = 0.600，95%置信区间[CI] 0.402-0.897）和CG + GG基因型（P = 0.033，HR = 0.681，95%CI 0.479-0.970）。在多变量分析中得到了类似的结果。进一步分层分析表明，rs 4919510与满足以下标准之一的患者的OS显著相关：男性、HbsAg阳性、甲胎蛋白（AFP）阳性、肿瘤大小> 5 cm、肝硬化、孤立性肿瘤、I + II pTNM分期或无肿瘤包膜。肝硬化组rs 4919510 CC基因型频率（22.9%，55/240）显著高于非肝硬化组（14.0%，17/121）（P = 0.047）。总之，我们的结果说明了miR-608 rs 4919510作为接受肿瘤手术切除的HCC患者的预后标志物的潜在作用。
Single nucleotide polymorphisms (SNPs) within microRNAs (miRNAs) are considered potential markers for risk and prognosis of various cancers. In the current study, we aimed to determine whether miR-608 rs4919510 affected hepatocellular carcinoma (HCC) prognosis. We genotyped rs4919510 using DNA from blood samples of 362 HCC patients receiving surgical resection of HCC tumor. Associations between rs4919510 and overall survival (OS) and demographic characteristics and clinical features were estimated using the Cox proportional hazards model. Results showed that HCC patients who carried the rs4919510 CC genotype had a significantly longer OS compared to those who carried the GG genotype (P = 0.013, hazard ratio [HR] = 0.600, 95 % confidence interval [CI] 0.402-0.897) and the CG + GG genotype (P = 0.033, HR = 0.681, 95 % CI 0.479-0.970) in univariate analysis. Similar results were obtained in multivariate analysis. Further stratification analysis indicated that rs4919510 was significantly associated with OS in patients who were satisfied with one of the following criteria: male gender, HbsAg-positive, alpha-fetoprotein (AFP)-positive, tumor size > 5 cm, cirrhosis, solitary tumor, I + II pTNM stage, or no tumor capsule. Finally, a significantly higher frequency of rs4919510 CC genotype was observed in patients with cirrhosis (22.9 %, 55/240) than those without cirrhosis (14.0 %, 17/121) (P = 0.047). In conclusion, our results illustrated the potential role of miR-608 rs4919510 as a prognostic marker for HCC patients undergoing surgical resection of the tumor.