ANTI-ACETYLCHOLINE RECEPTOR ANTIBODIES DIRECTED AGAINST THE ALPHA-BUNGAROTOXIN BINDING-SITE INDUCE A UNIQUE FORM OF EXPERIMENTAL MYASTHENIA
ANTI-ACETYLCHOLINE RECEPTOR ANTIBODIES DIRECTED AGAINST THE ALPHA-BUNGAROTOXIN BINDING-SITE INDUCE A UNIQUE FORM OF EXPERIMENTAL MYASTHENIA
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DOI：
10.1073/pnas.80.13.4089
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发表时间：
1983-01-01
期刊：
影响因子：
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通讯作者：
RICHMAN, DP
中科院分区：
文献类型：
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作者：
GOMEZ, CM;RICHMAN, DP
在7株针对烟碱型乙酰胆碱受体的大鼠单抗中，3株结合被α-银环蛇毒素阻断的抗体可引起雏鸡急性麻痹，而其余4株均无作用。在受影响的动物中，肌电反应在静脉注射后1h内出现减弱和减退。注射后，两种异常均得到改善。注射动物的肌肉未见组织学改变。与胆碱能结合部位结合的抗体，可能对乙酰胆碱受体产生药理阻断，可能在重症肌无力神经肌肉传递缺陷的发病机制中发挥重要作用。
Of 7 rat monoclonal antibodies directed against nicotinic acetylcholine receptor, the 3 whose binding was blocked by .alpha.-bungarotoxin produced acute paralysis in chicken hatchlings, whereas the 4 others had no effect. In the effected animals, weakness and decremental EMG responses appeared within 1 h after i.v. injection and both abnormalities improved after anticholinesterase administration. No histologic changes were seen in the muscle of injected animals. Antibodies binding in relationship to the cholinergic binding site, and presumably producing pharmacologic blockade of acetylcholine receptor, may play an important role in the pathogenesis of the defective neuromuscular transmission in myasthenia gravis.