Activation of Imd pathway in hemocyte confers infection resistance through humoral response in Drosophila.
Activation of Imd pathway in hemocyte confers infection resistance through humoral response in Drosophila.
复制标题
血细胞中 Imd 途径的激活通过果蝇的体液反应赋予感染抵抗力。
DOI：
10.1016/j.bbrc.2012.12.027
复制
发表时间：
2013
影响因子：
3.1
通讯作者：
et al.
中科院分区：
文献类型：
--
作者：
Bryce Nelson;et al.
当微生物入侵时，果蝇的先天免疫系统会产生两种不同但互补的反应，即体液和细胞。通过在免疫应答组织中异位表达，筛选能够赋予革兰氏阳性金黄色葡萄球菌抗性的基因，发现imd基因。这种耐药性不依赖于细胞防御，而可能是通过增加抗微生物肽（包括Toll途径报告基因drosomycin）的表达上调体液应答的结果。综上所述，Imd途径似乎能够在革兰氏阳性S.金黄色葡萄球菌，与Imd途径的传统作用的概念相反，Imd途径被认为主要负责对革兰氏阴性菌的抗性。
Upon microbial invasion the innate immune system of Drosophila melanogaster mounts a response that comes in two distinct but complimentary forms, humoral and cellular. A screen to find genes capable of conferring resistance to the Gram-positive Staphylococcus aureus upon ectopic expression in immune response tissues uncovered imd gene. This resistance was not dependent on cellular defenses but rather likely a result of upregulation of the humoral response through increased expression of antimicrobial peptides, including a Toll pathway reporter gene drosomycin. Taken together it appears that Imd pathway is capable of playing a role in resistance to the Gram-positive S. aureus, counter to notions of traditional roles of the Imd pathway thought largely to responsible for resistance to Gram-negative bacteria.