Development of the Drosophild olfactory system
Development of the Drosophild olfactory system
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DOI：
10.1007/978-0-387-78261-4_6
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发表时间：
2008-01-01
期刊：
影响因子：
--
通讯作者：
Hummel, Homas
中科院分区：
文献类型：
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作者：
Rodrigues, Veronica;Hummel, Homas
整个动物界的嗅觉系统以大量高度特化的神经元细胞类型为特征。外周感觉上皮中的嗅觉受体神经元（ORN）显示两个主要的分化特征：从受体基因的大基因组库中选择性表达单个气味受体，以及与初级嗅觉CNS靶区域中的单一类型的中继神经元的突触连接。在小鼠嗅觉系统中，气味受体本身在协调两种类型的ORN分化中发挥核心作用。果蝇的嗅觉系统，虽然类似的结构和功能组织相比，哺乳动物，似乎不涉及气味受体的选择或基因表达和靶细胞识别，表明不同的发育控制机制。在这一章中，我们总结了最近的研究结果，在果蝇的基因网络如何调节ORN规格和分化的外周感觉器官，以及如何不同的细胞相互作用和图案信号组织类特定的轴突和树突连接在中枢神经系统的目标领域。
The olfactory system throughout the animal kingdom is characterized by a large number of highly specialized neuronal cell types. Olfactory receptor neurons (ORNs) in the peripheral sensory epithelium display two main differentiation features: the selective expression of a single odorant receptor out of a large genomic repertoire of receptor genes and the synaptic connection to a single type of relay neuron in the primary olfactory CNS target area. In the mouse olfactory system, odorant receptors themselves play a central role in the coordination of both types of ORN differentiation. The olfactory system of Drosophila, although similar in structural and functional organization compared to mammals, does not seem to involve odorant receptors in the selection of OR gene expression and target cell recognition, suggesting distinct developmental control mechanisms. In this chapter we summarize recent findings in Drosophila of how gene networks regulate ORN specification and differentiation in the peripheral sensory organs as well as how different cellular interactions and patterning signals organize the class-specific axonal and dendritic connectivity in the CNS target area.