Quantitative genetics of Taura syndrome resistance in Pacific white shrimp (Penaeus vannamei): a cure model approach.
Quantitative genetics of Taura syndrome resistance in Pacific white shrimp (Penaeus vannamei): a cure model approach.
复制标题
DOI：
10.1186/1297-9686-43-14
复制
发表时间：
2011-03-21
期刊：
影响因子：
--
通讯作者：
Rye M
中科院分区：
文献类型：
--
作者：
Ødegård J;Gitterle T;Madsen P;Meuwissen TH;Yazdi MH;Gjerde B;Pulgarin C;Rye M
在水产养殖中，对传染病的抵抗力通常被评估为在暴露于病原体下直至死亡的时间。对于某些疾病，一部分个体可能表现为“治愈”（非易感），因此，所产生的生存时间可能是两个混淆的潜在特征的结果，即，耐力（个体危害）和易感性（是否有风险），这可以通过拟合治愈生存模型来解释。我们应用治愈模型的存活数据的太平洋白色虾（南美白对虾）挑战的桃拉综合征病毒，这是一个主要的病原体Panaeid虾种。总共有来自三代的513个全同胞家庭的15，261个个体在21个单独的测试（坦克）中进行了挑战测试。所有攻毒试验均进行至死亡率自然停止。采用混合治愈生存模型，使用Gibbs抽样，将易感性和耐受性作为单独的遗传性状，对事件发生前的时间数据进行分析。试验结束时的总死亡率为28%，而38%的人群被认为易患该疾病。易感性的潜在遗传力较高（0.41 ± 0.07），而耐力的潜在遗传力较低（0.07 ± 0.03）。此外，耐力和易感性是不同的遗传性状（rg = 0.22 ± 0.25）。估计育种值的耐力和敏感性只有中度相关（0.50），而估计育种值的经典模型分析的挑战测试生存（忽略治愈分数）密切相关，估计育种值的敏感性，但相关性较低，估计育种值的耐力。对于Taura综合征抗性，耐力和易感性显然是不同的遗传性状。然而，基于治愈模型的易感性遗传评估显示出与忽略这些数据的治愈分数的标准遗传评估的明确关联。使用当前的测试设计，在测试结束时观察到的生存时间和绝对生存的遗传变异最有可能由易感性的遗传变异主导。如果目的是降低易感性，则应避免提前终止激发试验或缩短随访期，因为这可能使选择的重点转向耐力而不是易感性。
In aquaculture breeding, resistance against infectious diseases is commonly assessed as time until death under exposure to a pathogen. For some diseases, a fraction of the individuals may appear as "cured" (non-susceptible), and the resulting survival time may thus be a result of two confounded underlying traits, i.e., endurance (individual hazard) and susceptibility (whether at risk or not), which may be accounted for by fitting a cure survival model. We applied a cure model to survival data of Pacific white shrimp (Penaeus vannamei) challenged with the Taura syndrome virus, which is one of the major pathogens of Panaeid shrimp species. In total, 15,261 individuals of 513 full-sib families from three generations were challenge-tested in 21 separate tests (tanks). All challenge-tests were run until mortality naturally ceased. Time-until-event data were analyzed with a mixed cure survival model using Gibbs sampling, treating susceptibility and endurance as separate genetic traits. Overall mortality at the end of test was 28%, while 38% of the population was considered susceptible to the disease. The estimated underlying heritability was high for susceptibility (0.41 ± 0.07), but low for endurance (0.07 ± 0.03). Furthermore, endurance and susceptibility were distinct genetic traits (rg = 0.22 ± 0.25). Estimated breeding values for endurance and susceptibility were only moderately correlated (0.50), while estimated breeding values from classical models for analysis of challenge-test survival (ignoring the cured fraction) were closely correlated with estimated breeding values for susceptibility, but less correlated with estimated breeding values for endurance. For Taura syndrome resistance, endurance and susceptibility are apparently distinct genetic traits. However, genetic evaluation of susceptibility based on the cure model showed clear associations with standard genetic evaluations that ignore the cure fraction for these data. Using the current testing design, genetic variation in observed survival time and absolute survival at the end of test were most likely dominated by genetic variation in susceptibility. If the aim is to reduce susceptibility, earlier termination of the challenge-test or back-truncation of the follow-up period should be avoided, as this may shift focus of selection towards endurance rather than susceptibility.
登录
查看更多内容
影响因子：
3.7
作者：
Bishop SC;Woolliams JA
通讯作者：
Woolliams JA
影响因子：
2
作者：
BAKKE, TA;JANSEN, PA;HANSEN, LP
通讯作者：
HANSEN, LP
影响因子：
3.3
作者：
Odegard, J.;Madsen, P.;Meuwissen, T. H. E.
通讯作者：
Meuwissen, T. H. E.
影响因子：
3.8
作者：
Corbiere, Fabien;Barillet, Francis;Joly, Pierre
通讯作者：
Joly, Pierre
影响因子：
4.5
作者：
Cock, James;Gitterle, Thomas;Rye, Morten
通讯作者：
Rye, Morten