Cumulative estrogen exposure and prospective memory in older women
Cumulative estrogen exposure and prospective memory in older women
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DOI：
10.1016/j.bandc.2012.05.001
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发表时间：
2012-10-01
影响因子：
2.5
通讯作者：
Hesson, Jacqueline
中科院分区：
文献类型：
--
作者：
Hesson, Jacqueline
这项研究考察了一生中雌激素的累积暴露，通过一个数学指数（雌激素暴露指数（ICEE））来估计，该指数包括已知影响一生中雌激素水平的变量（雌激素治疗时间长短、初潮和绝经年龄、绝经后体重指数、绝经后时间、无产期和母乳喂养持续时间）。对50名绝经后妇女（平均年龄= 69.3岁）进行前瞻性和回顾性记忆测量，如果她们现在或以前使用雌激素治疗，在绝经后5年内开始治疗。发现ICEE是前瞻记忆任务表现的重要预测因子(F(1) = 4.21, p = 0.046, eta（2)(p) = 0.084）。ICEE和回顾性记忆的表现之间没有显著的关系。研究结果表明，女性一生中雌激素的累积暴露水平会影响其未来生活的前瞻性记忆表现，内源性雌激素暴露的生殖和生物学标志物的影响是研究雌激素治疗对绝经后妇女认知功能影响的相关因素。此外，前瞻记忆的表现与ICEE有关，而回顾记忆的表现与ICEE无关，这一发现进一步支持了额叶皮质可能对雌激素特别敏感的理论。(C) 2012爱思唯尔公司版权所有。
This study looked at cumulative lifetime estrogen exposure, as estimated with a mathematical index (Index of Cumulative Estrogen Exposure (ICEE)) that included variables (length of time on estrogen therapy, age at menarche and menopause, postmenopausal body mass index, time since menopause, nulliparity and duration of breastfeeding) known to influence estrogen levels across the life span, and performance on prospective and retrospective memory measures in a group of 50 postmenopausal women (mean age = 69.3 years) who, if they were current or former users of estrogen therapy, had started therapy within 5 years of menopause. The ICEE was found to be a significant predictor of performance on the Prospective Memory task (F(1) = 4.21, p = .046, eta(2)(p) = .084). No significant relationship was noted between the ICEE and performance on measures of retrospective memory. The results suggest that the level of cumulative lifetime exposure to estrogen a woman has influences her prospective memory performance later in life and that the influence of reproductive and biological markers of endogenous estrogen exposure are relevant factors to consider when studying the effect of estrogen therapy on cognitive functioning in postmenopausal women. In addition, the finding that performance on a measure of prospective memory, but not performance on measures of retrospective memory, was associated with the ICEE adds further support to the theory that the frontal cortex may be especially sensitive to estrogen. (C) 2012 Elsevier Inc. All rights reserved.