Increased cyclooxygenase-2 expression is correlated with suppressed antitumor immunity in cervical adenocarcinomas
Increased cyclooxygenase-2 expression is correlated with suppressed antitumor immunity in cervical adenocarcinomas
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DOI：
10.1111/j.1525-1438.2006.00385.x
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发表时间：
2006-03-01
影响因子：
4.8
通讯作者：
Fujii, S
中科院分区：
文献类型：
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作者：
Chen, TH;Fukuhara, K;Fujii, S
环氧合酶-2(COX-2)抑制可抑制多种肿瘤的生长。通过增加细胞毒性淋巴细胞增强抗肿瘤免疫功能可能是COX-2抑制的重要机制。在宫颈癌中，腺癌表现出更多的侵袭性行为，并过度表达COX-2。免疫组织化学方法检测COX-2的表达及CD8+淋巴细胞的浸润情况。我们研究了55例子宫颈腺癌组织中COX-2的表达和CD8+淋巴细胞的浸润情况。用半定量方法检测COX-2表达和肿瘤间质CD8+淋巴细胞。在x200显微镜下计数肿瘤上皮内淋巴细胞。研究这些数据与其他临床病理特征之间的相关性。在55例宫颈鳞癌中，37例(67.3%)表达COX-2。5年内死亡的患者COX-2表达水平高于存活者(100%vs58.1%，P<；0.05)。患者的上皮内CD8+淋巴细胞计数也低于存活患者(3.4vs26.4，P<；0.05)。COX-2表达与肿瘤上皮内淋巴细胞计数呈负相关(相关指数：-0.38，P<；0.01)。COX-2表达上调和较少的肿瘤上皮内CD8+淋巴细胞计数是宫颈腺癌患者预后不良的指标。COX-2可能在抑制宫颈鳞癌宿主抗肿瘤免疫中起重要作用。
Cyclooxygenase-2 (COX-2) inhibition suppressed the growth of various tumors. The augmentation of antitumor immunity by increasing cytotoxic lymphocytes may be an important mechanism for COX-2 inhibition. Among cervical cancers, adenocarcinomas present more aggressive behavior and overexpressed COX-2. The expression of COX-2 and the CD8+ lymphocyte infiltrations were evaluated in this study by immunohistochemistry. We studied COX-2 expression and CD8+ lymphocyte infiltration in 55 women with cervical adenocarcinomas. COX-2 expression and tumor stromal CD8+ lymphocytes were evaluated by semiquantified methods. Tumor intraepithelial lymphocytes were counted under microscopic field of x200. Correlations between these data and other clinicopathologic features were investigated. Thirty-seven out of 55 (67.3%) cervical adenocarcinomas significantly expressed COX-2. Patients who died within 5 years showed higher percentage of COX-2 expression than survivors (100% vs 58.1%, P < 0.05). Victims also showed lesser intraepithelial CD8+ lymphocyte counts than survived patients (3.4 vs 26.4, P < 0.05). COX-2 expression and tumor intraepithelial lymphocyte count were reversely correlated with each other (correlation index: -0.38, P < 0.01). Up-regulated COX-2 expression and lesser tumor intraepithelial CD8+ lymphocyte count are poor prognostic indicators for cervical adenocarcinoma patients. COX-2 may play an important role in the suppression of host antitumor immunity in cervical adenocarcinomas.