Functional domains of GABAA receptors.
Functional domains of GABAA receptors.
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DOI：
10.1016/s0165-6147(00)89009-4
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发表时间：
1995-05
影响因子：
13.8
通讯作者：
Geoffrey B. Smith;R. Olsen
中科院分区：
文献类型：
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作者：
Geoffrey B. Smith;R. Olsen
递质门控离子通道介导快速突触传递，例如，在神经肌肉接头使用乙酰胆碱，在中枢神经系统主要使用氨基酸谷氨酸和GABA。GABAA受体Cl型−通道与烟碱型乙酰胆碱受体和抑制性甘氨酸受体等超家族通道具有序列同源性。在这篇文章中，杰弗里·史密斯和理查德·奥尔森讨论了最近对GABA受体的亲和标记和定点突变研究，这些研究已经确定了激动剂和变构调节剂结合以及离子通道壁形成所必需的氨基酸残基。所确定的结构域与递质门控离子通道超家族其他成员的结果一致，表明该家族一个成员的结构模型也适用于其他成员。
The transmitter-gated ion channels mediate rapid synaptic transmission, for example, at the neuromuscular junction using acetylcholine and in the CNS using primarily the amino acids glutamate and GABA. GABAA-receptor Cl−channels share sequence homology with a superfamily of these channels including nicotinic acetylcholine receptor and inhibitory glycine receptor. In this article,Geoffrey Smith and Richard Olsendiscuss recent affinity labelling and sitedirected mutagenesis studies on GABAAreceptors that have identified amino acid residues essential for binding of agonists and allosteric modulators as well as the ion channel wall formation. The structural domains identified are consistent with results obtained with other members of the transmitter-gated ion channel superfamily and suggest that structural models for one member of the family may apply to the others as well.