Bioaccumulation, metabolism, and risk assessment of phenolic endocrine disrupting chemicals in specific tissues of wild fish
Bioaccumulation, metabolism, and risk assessment of phenolic endocrine disrupting chemicals in specific tissues of wild fish
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野生鱼类特定组织中酚类内分泌干扰物的生物累积、代谢和风险评估
DOI：
10.1016/j.chemosphere.2019.03.187
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发表时间：
2019-07-01
期刊：
影响因子：
8.8
通讯作者：
Ying, Guang-Guo
中科院分区：
文献类型：
--
作者：
Lv, Yin-Zhi;Yao, Li;Ying, Guang-Guo
酚类内分泌干扰物（EDCs）在环境中普遍存在，具有潜在的生物富集性，对野生动物和人类构成极大的危害。研究了6种酚类内分泌干扰物（双酚A（BPA）、4-叔辛基酚（4-t-OP）、4-壬基酚（4-NP）、雌酮（E1）、17 β-雌二醇（E2）和17 α-炔雌醇（EE2））在珠江水系野生鱼类体内的累积、代谢和人体健康风险。除EE2外，其他五种内分泌干扰物在四种鱼组织（胆汁、肝脏、血浆和肌肉）中至少有一种被检测到。BPA和4-NP在所有组织中的浓度均高于4-t-OP、E1和E2。胆汁、肝脏、血浆和肌肉中内分泌干扰物的对数生物累积因子中位数分别为3.86 - 4.52、2.06 - 3.16、2.69 - 3.87和1.34 - 2.30，表明鱼胆汁中的生物累积潜力高于其他组织。鱼胆汁和肝脏中葡萄糖醛酸苷/硫酸酯结合型内分泌干扰物的含量高于血浆和肌肉，表明肝脏和胆汁在鱼体内酚类内分泌干扰物的代谢和排泄中起重要作用。每种化合物的计算危害商数值均低于1，表明食用鱼类对人类健康的风险较低。(C)2019爱思唯尔有限公司版权所有。
Phenolic endocrine disrupting chemicals (EDCs) may pose a great hazard to wildlife and humans, owing to their ubiquitous presence in the environment and potential bioaccumulation ability. We investigated the bioaccumulation, metabolism, and human health risks of six phenolic EDCs, including bisphenol A (BPA), 4-tert-octylphenol (4-t-OP), 4-nonylphenol (4-NP), estrone (E1), 17 beta-estradiol (E2), and 17 alpha-ethinylestradiol (EE2), in wild fish from the Pearl River system, South China. Except EE2, the other five EDCs were detected in at least one of the four fish tissues (bile, liver, plasma, and muscle). The concentrations of BPA and 4-NP were greater than those of 4-t-OP, E1, and E2 in all tissues. The median values of log bioaccumulation factors for EDCs at the range of 3.86-4.52 in bile, 2.06-3.16 in liver, 2.69 -3.87 in plasma, and 1.34-2.30 in muscle, indicating a higher bioaccumulation potential in fish bile than in other tissues. Greater levels of glucuronide/sulfate conjugated EDCs were found in fish bile and liver than in the plasma and muscle, suggesting that the liver and bile played an important role in the metabolism and excretion of phenolic EDCs in fish. The calculated hazard quotient values were below 1 for each compound, implying low risk to human health by intake of edible fish. (C) 2019 Elsevier Ltd. All rights reserved.