A valve powered by earthworm muscle with both electrical and 100% chemical control
A valve powered by earthworm muscle with both electrical and 100% chemical control
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DOI：
10.1038/s41598-019-44116-3
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发表时间：
2019-07
影响因子：
4.6
通讯作者：
Yo Tanaka;Shun-ichi Funano;Y. Noguchi;Yaxiaer Yalikun;N. Kamamichi
中科院分区：
文献类型：
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作者：
Yo Tanaka;Shun-ichi Funano;Y. Noguchi;Yaxiaer Yalikun;N. Kamamichi
结合微器件和细胞机械功能的生物微执行器的开发一直是一个活跃的研究领域，因为它们具有包括高机械完整性和生物相容性在内的理想特性。尽管报道了各种类型的设备，但使用原样的天然肌肉组织应该更有效。蚯蚓肌肉驱动的阀门已经被创造出来。通过化学（乙酰胆碱）刺激观察到长时间（超过2分钟）和可重复的位移。在乙酰胆碱溶液(100mM)的刺激下，肌肉(1cm××3cm)产生的力在2分钟内平均为1.57mN。我们演示了一种片上阀门，可以通过肌肉收缩来停止恒压流。对于电控制，短脉冲刺激用于连续且可重复的肌肉收缩。响应时间为3秒，耐压为3.0kPa。然后使用化学刺激来持续肌肉收缩。响应时间为42秒，耐压为1.5kPa。 ON（关闭）状态保持至少2分钟。片上阀门被证明可以通过肌肉收缩来停止恒压流。这是 100% 化学驱动和控制的基于肌肉的阀门的首次演示。
Development of bio-microactuators combining microdevices and cellular mechanical functions has been an active research field owing to their desirable properties including high mechanical integrity and biocompatibility. Although various types of devices were reported, the use of as-is natural muscle tissue should be more effective. An earthworm muscle-driven valve has been created. Long-time (more than 2 min) and repeatable displacement was observed by chemical (acetylcholine) stimulation. The generated force of the muscle (1 cm × 3 cm) was 1.57 mN on average for 2 min by the acetylcholine solution (100 mM) stimulation. We demonstrated an on-chip valve that stopped the constant pressure flow by the muscle contraction. For electrical control, short pulse stimulation was used for the continuous and repeatable muscle contraction. The response time was 3 s, and the pressure resistance was 3.0 kPa. Chemical stimulation was then used for continuous muscle contraction. The response time was 42 s, and the pressure resistance was 1.5 kPa. The ON (closed) state was kept for at least 2 min. An on-chip valve was demonstrated that stopped the constant pressure flow by the muscle contraction. This is the first demonstration of the muscle-based valve that is 100% chemically actuated and controlled.