MINMOD - A COMPUTER-PROGRAM TO CALCULATE INSULIN SENSITIVITY AND PANCREATIC RESPONSIVITY FROM THE FREQUENTLY SAMPLED INTRAVENOUS GLUCOSE-TOLERANCE TEST
MINMOD - A COMPUTER-PROGRAM TO CALCULATE INSULIN SENSITIVITY AND PANCREATIC RESPONSIVITY FROM THE FREQUENTLY SAMPLED INTRAVENOUS GLUCOSE-TOLERANCE TEST
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DOI：
10.1016/0169-2607(86)90106-9
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发表时间：
1986-10-01
影响因子：
6.1
通讯作者：
BERGMAN, RN
中科院分区：
文献类型：
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作者：
PACINI, G;BERGMAN, RN
胰岛素敏感性和胰腺反应性是控制糖耐量的两个主要因素。我们提出了一种方法来测量这两个因素，使用计算机分析的频繁采样静脉葡萄糖耐量试验（FSIGT）。这种“最小建模方法”适合两个数学模型与FSIGT葡萄糖和胰岛素数据;一个葡萄糖消失和胰岛素动力学之一。MINMOD是一个计算机程序，它可以识别每个人的模型参数。使用非线性最小二乘估计技术，采用梯度型估计算法，并根据“灵敏度方法”计算一阶导数（解析未知）。该程序产生的参数估计和精度的估计。从模型参数中，可以提取四个指数：（1）SG，葡萄糖本身在基础胰岛素下增强其自身消失的能力，（2）S1，组织胰岛素敏感性指数，（3）v φ 1，第一位胰腺响应性，和（4）v φ 2，第二相胰腺响应性。这四个特征参数已被证明代表一个单一的个人的综合代谢画像。
Insulin sensitivity and pancreatic responsitivity are the two main factors controlling glucose tolerance. We have proposed a method for measuring these two factors, using computer analysis of a frequently-sampled intravenous glucose tolerance test (FSIGT). This "minimal modeling approach'' fits two mathematical models with FSIGT glucose and insulin data; one of glucose disappearance and one of insulin kinetics. MINMOD is the computer program which identifies the model parameters for each individual. A nonlinear least squares estimation technique is used, employing a gradient-type of estimation algorithm, and the first derivatives (not known analytically) are computed according to the ''sensitivity approach''. The program yields the parameter estimates and the precision of their estimation. From the model parameters, it is possible to extract four indices: (1) SG, the ability of glucose per se to enhance its own disappearance at basal insulin, (2) S1, the tissue insulin sensitivity index, (3) .vphi.1, first place pancreatic responsivity, and (4) .vphi.2, second phase pancreatic responsitivity. These four characteristic parameters have been shown to represent an integrated metabolic portrait of a single individual.