Harnessing Extracellular Matrix Biology for Tumor Drug Delivery.
Harnessing Extracellular Matrix Biology for Tumor Drug Delivery.
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DOI：
10.3390/jpm11020088
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发表时间：
2021-01-31
影响因子：
--
通讯作者：
Ghandehari H
中科院分区：
文献类型：
--
作者：
Subrahmanyam N;Ghandehari H
细胞外基质 (ECM) 通过由多种纤维蛋白、酶、受体和其他成分维持的严格控制的相互关系，在细胞生命中发挥着积极作用。它还高度参与癌症进展。由于其在癌症病因学中的作用，ECM 在多个方面为癌症治疗提供了机会。肿瘤相关 ECM 中存在信号分子、酶表达、蛋白质结构、受体相互作用等水平的靶标。特别是，ECM 通过其与细胞的信号相互作用参与肿瘤的侵袭性。通过利用肿瘤微环境的生物学及其提供的干预机会，ECM 已被研究作为治疗靶点，以促进药物输送，并作为肿瘤进展和治疗干预的预后或诊断标志物。这篇综述总结了肿瘤 ECM 生物学，因为它与药物输送相关，重点是针对 ECM 的设计参数。
The extracellular matrix (ECM) plays an active role in cell life through a tightly controlled reciprocal relationship maintained by several fibrous proteins, enzymes, receptors, and other components. It is also highly involved in cancer progression. Because of its role in cancer etiology, the ECM holds opportunities for cancer therapy on several fronts. There are targets in the tumor-associated ECM at the level of signaling molecules, enzyme expression, protein structure, receptor interactions, and others. In particular, the ECM is implicated in invasiveness of tumors through its signaling interactions with cells. By capitalizing on the biology of the tumor microenvironment and the opportunities it presents for intervention, the ECM has been investigated as a therapeutic target, to facilitate drug delivery, and as a prognostic or diagnostic marker for tumor progression and therapeutic intervention. This review summarizes the tumor ECM biology as it relates to drug delivery with emphasis on design parameters targeting the ECM.
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