Reduced vagal tone in women with the FMR1 premutation is associated with FMR1 mRNA but not depression or anxiety.
Reduced vagal tone in women with the FMR1 premutation is associated with FMR1 mRNA but not depression or anxiety.
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DOI：
10.1186/s11689-017-9197-6
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发表时间：
2017
影响因子：
4.9
通讯作者：
Roberts JE
中科院分区：
文献类型：
--
作者：
Klusek J;LaFauci G;Adayev T;Brown WT;Tassone F;Roberts JE
自主神经功能障碍与一系列心理状况有关，包括抑郁和焦虑。脆性X智力低下-1（FMR 1）前突变是一种常见的基因突变，影响约1：150的妇女，并与心理脆弱性有关。本研究检测了FMR 1前突变女性和对照女性的自主神经功能的心脏指标，作为可能与FMR 1相关的心理风险的潜在生物标志物。在35名FMR 1前突变女性和28名对照组中测量了基线心搏间期和呼吸性窦性心律失常（测量副交感迷走神经张力）。这些妇女完成了焦虑和抑郁问卷。FMR 1遗传指数（即，对前突变组进行CGG重复序列、定量FMRP、FMR 1 mRNA、活化率的测定。呼吸性窦性心律失常在FMR 1前突变组相对于对照组减少。虽然抑郁症状与对照组女性呼吸性窦性心律失常的减少有关，但这些变量与FMR 1前突变无关。FMR 1 mRNA升高与呼吸性窦性心律失常相关。FMR 1前突变的女性表现出自主神经功能失调，其特征是迷走神经张力降低。与在一般人群和研究对照中观察到的模式不同，迷走神经活动和抑郁症状在FMR 1前突变的女性中解耦，这表明自主调节和精神病理症状之间的独立性是非典型的，可能是FMR 1前突变特有的。迷走神经张力和mRNA之间的关联表明与FMR 1相关的分子变异在自主调节中起作用。
Autonomic dysfunction is implicated in a range of psychological conditions, including depression and anxiety. The fragile X mental retardation-1 (FMR1) premutation is a common genetic mutation that affects ~1:150 women and is associated with psychological vulnerability. This study examined cardiac indicators of autonomic function among women with the FMR1 premutation and control women as potential biomarkers for psychological risk that may be linked to FMR1. Baseline inter-beat interval and respiratory sinus arrhythmia (a measure of parasympathetic vagal tone) were measured in 35 women with the FMR1 premutation and 28 controls. The women completed anxiety and depression questionnaires. FMR1 genetic indices (i.e., CGG repeat, quantitative FMRP, FMR1 mRNA, activation ratio) were obtained for the premutation group. Respiratory sinus arrhythmia was reduced in the FMR1 premutation group relative to controls. While depression symptoms were associated with reduced respiratory sinus arrhythmia among control women, these variables were unrelated in the FMR1 premutation. Elevated FMR1 mRNA was associated with higher respiratory sinus arrhythmia. Women with the FMR1 premutation demonstrated autonomic dysregulation characterized by reduced vagal tone. Unlike patterns observed in the general population and in study controls, vagal activity and depression symptoms were decoupled in women with the FMR1 premutation, suggesting independence between autonomic regulation and psychopathological symptoms that is atypical and potentially specific to the FMR1 premutation. The association between vagal tone and mRNA suggests that molecular variation associated with FMR1 plays a role in autonomic regulation.