An unresolved LINC in the nuclear envelope.
An unresolved LINC in the nuclear envelope.
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DOI：
10.1007/s12195-016-0431-1
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发表时间：
2016-06
影响因子：
2.8
通讯作者：
Agrawal A
中科院分区：
文献类型：
--
作者：
Torbati M;Lele TP;Agrawal A
核膜将核质与细胞质分离，是真核细胞的一个关键特征。核膜结构由两个同心的膜壳组成，它们在多个位点融合，但在膜的其余部分上保持30-50 nm的均匀间隔。研究已经揭示了许多核蛋白在形成和维持核膜结构中的作用。然而，在建立几何的基本力和物理机制上缺乏共识。这篇评论的目的是讨论最近的研究结果，在膜力学的背景下，努力确定开放的问题和可能的答案。
The nuclear envelope segregates the nucleoplasm from the cytoplasm and is a key feature of eukaryotic cells. Nuclear envelope architecture is comprised of two concentric membrane shells which fuse at multiple sites and yet maintain a uniform separation of 30–50 nm over the rest of the membrane. Studies have revealed the roles for numerous nuclear proteins in forming and maintaining the architecture of the nuclear envelope. However, there is a lack of consensus on the fundamental forces and physical mechanisms that establish the geometry. The objective of this review is to discuss recent findings in the context of membrane mechanics in an effort to define open questions and possible answers.