Streptococcus pneumoniae's Virulence and Host Immunity: Aging, Diagnostics, and Prevention.
Streptococcus pneumoniae's Virulence and Host Immunity: Aging, Diagnostics, and Prevention.
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DOI：
10.3389/fimmu.2018.01366
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发表时间：
2018
影响因子：
7.3
通讯作者：
Mias GI
中科院分区：
文献类型：
--
作者：
Brooks LRK;Mias GI
肺炎链球菌是一种传染性病原体，造成全世界数百万人死亡。由这种细菌引起的疾病被归类为肺炎球菌疾病。这种病原体在其宿主的鼻咽部无症状地定植，但随着时间的推移可以迁移到无菌组织和器官并引起感染。肺炎是目前最常见的肺炎球菌疾病。肺炎球菌肺炎是一个全球性的健康问题，严重影响五岁以下儿童以及老年人和已有健康状况的个人。肺炎链球菌具有多种毒力因子，可促进黏附，侵袭宿主组织，并使其逃脱宿主免疫防御。清楚地了解肺炎链球菌的毒力因子、宿主免疫反应，并检查目前可用的诊断、治疗和疾病预防技术，将有助于更好地调节病原体及其疾病。在预防疾病方面，其他考虑必须包括年龄对疫苗反应和疫苗效力的影响。正在进行的工作旨在改进目前的疫苗接种模式，包括使用血清型无关的疫苗，如蛋白质和全细胞疫苗。扩大我们对肺炎链球菌的生物学和相关宿主免疫反应的知识，对于我们改善肺炎球菌疾病的诊断、治疗和改善患者的前景至关重要。
Streptococcus pneumoniae is an infectious pathogen responsible for millions of deaths worldwide. Diseases caused by this bacterium are classified as pneumococcal diseases. This pathogen colonizes the nasopharynx of its host asymptomatically, but overtime can migrate to sterile tissues and organs and cause infections. Pneumonia is currently the most common pneumococcal disease. Pneumococcal pneumonia is a global health concern and vastly affects children under the age of five as well as the elderly and individuals with pre-existing health conditions. S. pneumoniae has a large selection of virulence factors that promote adherence, invasion of host tissues, and allows it to escape host immune defenses. A clear understanding of S. pneumoniae’s virulence factors, host immune responses, and examining the current techniques available for diagnosis, treatment, and disease prevention will allow for better regulation of the pathogen and its diseases. In terms of disease prevention, other considerations must include the effects of age on responses to vaccines and vaccine efficacy. Ongoing work aims to improve on current vaccination paradigms by including the use of serotype-independent vaccines, such as protein and whole cell vaccines. Extending our knowledge of the biology of, and associated host immune response to S. pneumoniae is paramount for our improvement of pneumococcal disease diagnosis, treatment, and improvement of patient outlook.
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影响因子：
4.2
作者：
Althouse BM;Hammitt LL;Grant L;Wagner BG;Reid R;Larzelere-Hinton F;Weatherholtz R;Klugman KP;Rodgers GL;O'Brien KL;Hu H
通讯作者：
Hu H
DOI：
10.1186/cc8850
发表时间：
2010
期刊：
Critical care (London, England)
影响因子：
--
作者：
Anas A;van der Poll T;de Vos AF
通讯作者：
de Vos AF
影响因子：
6.7
作者：
Ali YM;Lynch NJ;Haleem KS;Fujita T;Endo Y;Hansen S;Holmskov U;Takahashi K;Stahl GL;Dudler T;Girija UV;Wallis R;Kadioglu A;Stover CM;Andrew PW;Schwaeble WJ
通讯作者：
Schwaeble WJ
影响因子：
3.6
作者：
Alcoba G;Keitel K;Maspoli V;Lacroix L;Manzano S;Gehri M;Tabin R;Gervaix A;Galetto-Lacour A
通讯作者：
Galetto-Lacour A
影响因子：
56.3
作者：
Andrews, Nick J.;Waight, Pauline A.;Goldblatt, David
通讯作者：
Goldblatt, David