[2,1-c][1,4]benzodiazepine (PBD)-distamycin hybrid inhibits DNA binding to transcription factor Sp1
[2,1-c][1,4]benzodiazepine (PBD)-distamycin hybrid inhibits DNA binding to transcription factor Sp1
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DOI：
10.1080/15257770008033045
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发表时间：
2000-01-01
影响因子：
1.3
通讯作者：
Gambari, R
中科院分区：
文献类型：
--
作者：
Baraldi, PG;Cacciari, B;Gambari, R
我们设计并合成了杂合物6，将小沟结合剂偏端霉素A和吡咯并[2，1-c][1，4]苯并二氮杂卓（PBD）4结合制备，与天然存在的安曲霉素（2）和DC-81（3）相关。本文研究了化合物6对DNA与转录因子Spl分子相互作用的影响。结果表明，PBD-偏端霉素杂合物是Sp1/DNA相互作用的强抑制剂。
We designed and synthesized the hybrid 6, prepared combining the minor groove binders distamycin A and pyrrolo [2,1-c][1,4] benzodiazepine (PBD) 4, related to the natural occurring anthramycin (2) and DC-81 (3). In this paper, the effects of the compound 6 on molecular interactions between DNA and transcription factor Spl were studied. The results obtained demonstrate that PBD-distamycin hybrid is a powerful inhibitor of Sp1/DNA interactions.