ASYMMETRIC SYNTHESIS OF 2-,3-, AND 4-METHYLOCTANOIC ACIDS
ASYMMETRIC SYNTHESIS OF 2-,3-, AND 4-METHYLOCTANOIC ACIDS
复制标题
2-,3-, 和 4-甲基辛酸的不对称合成
DOI：
10.1080/00304949009458196
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发表时间：
1990
期刊：
影响因子：
--
通讯作者：
J. Gazzillo
中科院分区：
文献类型：
--
作者：
P. Sonnet;J. Gazzillo
用二异丙基氨基锂（LDA）将辛酸转化为二价阴离子，并用碘甲烷烷基化（方案1）。所得2-甲基辛酸通过其酰基卤转化为与（R）-或（S）-α-苯乙胺（PEA）的酰胺。用乙醇重结晶得到纯的（> 99%）非对映异构体，用气-液色谱监测
Octanoic acid was converted to a dianion with lithium diisopropylamide (LDA) and alkylated with methyl iodide (Scheme 1). The resulting 2-methyloctanoic acid was converted via its acid halide, to arnide with either (R)-, or (S)-a-phenylethylamine (PEA). Pure (> 99%) diastere-omrs were obtained by recrystallization from ethanol monitored by gas-liquid chromatography