DNA Base Detection Using a Single-Layer MoS2
DNA Base Detection Using a Single-Layer MoS2
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DOI：
10.1021/nn5029295
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发表时间：
2014-08-01
期刊：
影响因子：
17.1
通讯作者：
Aluru, Narayana R.
中科院分区：
文献类型：
--
作者：
Farimani, Amir Barati;Min, Kyoungmin;Aluru, Narayana R.
基于纳米孔的DNA测序已经导致DNA碱基的快速和高分辨率识别和检测。固态和生物纳米孔具有低信噪比（SNR）（< 10），并且通常太厚（> 5 nm）而不能以单碱基分辨率读取。石墨烯中的纳米孔是一种具有亚纳米厚度的2-D材料，在DNA离子电流下具有类似于3的SNR。在这份报告中，使用原子和量子模拟，我们发现单层MoS 2是一种非凡的材料（SNR > 15），用于两种竞争技术的DNA测序（即，纳米孔和纳米通道）。MoS 2纳米孔显示四种不同的离子电流信号，用于具有低噪声的单个核碱基检测。此外，单层MoS 2显示出每个基的总态密度的特征变化/响应。与其他纳米材料相比，MoS 2的带隙显著改变（例如，当碱基被放置在原始的MoS 2和扶手椅型MoS 2纳米载体的顶部时，MoS 2纳米孔（例如，石墨烯、h-BN和硅纳米线）的尺寸和大小是相同的，从而使MoS 2成为通过横向电流隧穿测量进行碱基检测的有前景的材料。
Nanopore-based DNA sequencing has led to fast and high-resolution recognition and detection of DNA bases. Solid-state and biological nanopores have low signal-to-noise ratio (SNR) (< 10) and are generally too thick (> 5 nm) to be able to read at single-base resolution. A nanopore in graphene, a 2-D material with sub-nanometer thickness, has a SNR of similar to 3 under DNA ionic current In this report, using atomistic and quantum simulations, we find that a single layer MoS2 is an extraordinary material (with a SNR > 15) for DNA sequencing by two competing technologies (i.e., nanopore and nanochannel). A MoS2 nanopore shows four distinct ionic current signals for single-nucleobase detection with low noise. In addition, a single-layer MoS2 shows a characteristic change/response in the total density of states for each base. The band gap of MoS2 is significantly changed compared to other nanomaterials (e.g., graphene, h-BN, and silicon nanowire) when bases are placed on top of the pristine MoS2 and armchair MoS2 nanoribbon, thus making MoS2 a promising material for base detection via transverse current tunneling measurement MoS2 nanopore benefits from a craftable pore architecture (combination of Mo and S atoms at the edge) which can be engineered to obtain the optimum sequencing signals.