Autoimmune sensorineural hearing loss.
Autoimmune sensorineural hearing loss.
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DOI：
10.1046/j.0307-7772.2003.00738.x
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发表时间：
2003-12
期刊：
影响因子：
--
通讯作者：
J. Mathews;B. N. Kumar
中科院分区：
文献类型：
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作者：
J. Mathews;B. N. Kumar
自1979年McCabe描述自身免疫性感音神经性耳聋以来，其作为一种临床实体已被越来越多地认识到。认识和正确处理这种情况很重要，因为它是极少数可以通过药物治疗成功治疗的感音神经性听力损失形式之一。最近的研究提供了实验证据，表明免疫过程可以导致动物和人类的感觉神经性听力损失。然而，内耳内的抗原靶点是多样的，因此，内耳受到特异性自身免疫损害的确凿证据一直难以捉摸。本文就自身免疫性耳聋的病因和发病机制的最新研究进展作一综述。在实验室诊断和治疗这种有趣的疾病的最新进展也被描述。
Autoimmune sensorineural hearing loss has been increasingly recognized as a clinical entity since its description by McCabe in 1979. Recognition and proper management of this condition is important, as it is one of the very few forms of sensorineural hearing loss that can be successfully treated by medical therapy. Recent studies have provided experimental evidence to suggest that immune processes can cause sensorineural hearing loss in animals and humans. However, antigenic targets within the inner ear are diverse and as a result conclusive evidence for specific autoimmune damage to the inner ear has been elusive. This review focuses on the recent progress in understanding of the aetio-pathogenesis of autoimmune hearing loss along with a description of the various clinical conditions in which they occur. Recent advances in the laboratory diagnosis and management of this interesting condition are also described.