Incidence of urethral stricture after primary treatment for prostate cancer: Data from CaPSURE
Incidence of urethral stricture after primary treatment for prostate cancer: Data from CaPSURE
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DOI：
10.1016/j.juro.2007.03.126
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发表时间：
2007-08-01
影响因子：
6.6
通讯作者：
Carroll, Peter R.
中科院分区：
文献类型：
--
作者：
Elliott, Sean P.;Meng, Maxwell V.;Carroll, Peter R.
目的：我们确定的发病率治疗尿道狭窄，包括膀胱颈挛缩，初步治疗后的临床局限性prostate cancer.Materials和Methods：共6,597名男性新诊断的，局限性前列腺癌和无尿道狭窄疾病的历史中确定的CaPSURE（TM）数据库。治疗方式包括根治性前列腺切除术、外照射放射治疗、近距离放射治疗、冷冻治疗、雄激素剥夺治疗、根治性前列腺切除术加外照射放射治疗、近距离放射治疗加外照射放射治疗和观察等待。查询数据库中与前列腺癌治疗后狭窄治疗一致的患者报告病史或国际疾病分类第9版/通用手术术语代码。采用Kaplan-Meier法检测梗阻时间。狭窄的危险因素在多变量考克斯比例风险model.Results：狭窄治疗的发病率为344 6,597例（5.2%，范围1.1%至8.4%的前列腺癌治疗类型）。中位随访时间为2.7年。在多变量模型中，主要治疗类型（p < 0.0001），体重指数（p < 0.0001），
Purpose: We determined the incidence of treatment for urethral stricture, including bladder neck contracture, after primary treatment for clinically localized prostate cancer.Materials and Methods: A total of 6,597 men with newly diagnosed, localized prostate cancer and no history of urethral stricture disease were identified in the CaPSURE (TM) database. Treatment modalities included radical prostatectomy, external beam radiotherapy, brachytherapy, cryotherapy, androgen deprivation therapy, radical prostatectomy plus external beam radiotherapy, brachytherapy plus external beam radiotherapy and watchful waiting. The database was queried for patient reported history or International Classification of Diseases, 9th revision/Common Procedural Terminology codes consistent with stricture treatment after prostate cancer therapy. Time to obstruction was examined by the Kaplan-Meier method. Risk factors for stricture were examined in a multivariate Cox proportional hazards model.Results: The incidence of stricture treatment was 344 of 6,597 cases (5.2%, range 1.1% to 8.4% by prostate cancer treatment type). Median followup was 2.7 years. In the multivariate model primary treatment type (p < 0.0001), body mass index (p