Effects of methadone on cognition, mood and craving in detoxifying opiate addicts: a dose-response study
Effects of methadone on cognition, mood and craving in detoxifying opiate addicts: a dose-response study
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DOI：
10.1007/s002130000628
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发表时间：
2001-03-01
影响因子：
3.4
通讯作者：
Wanigaratne, S
中科院分区：
文献类型：
--
作者：
Curran, HV;Kleckham, J;Wanigaratne, S
基本原理：美沙酮是阿片类药物依赖的最广泛的药物治疗，但相对而言，它对认知和精神功能，药物渴望和情绪的影响知之甚少。Objective.本研究的目的是评估美沙酮的急性影响的患者入院阿片类药物戒毒计划，方法：患者被随机分配到两组谁收到无论是50%或100%的每日稳定剂量，和安慰剂，在一个双盲，交叉设计。20例患者完成了研究，所有患者均在2个单独的检测日接受给药前和给药后评估。结果如下：执行任务挖掘情景记忆（延迟回忆散文段落）显着受损后，100%每日剂量的美沙酮。美沙酮治疗对渴望或情绪没有影响。患者无法区分美沙酮和安慰剂治疗。结论：单剂量美沙酮可导致平均使用海洛因超过10年的患者的情景记忆受损。这种损害可以通过分次给予美沙酮来避免。
Rationale: Methadone is the most widespread pharmacological treatment for opiate dependency but relatively little is known of its effects on cognitive and psychomotor functioning, drug craving and mood. Objective. The present study aimed to assess the acute effects of methadone in patients admitted to an opiate detoxification programme, Methods: Patients were randomly allocated to one of two groups who received either 50% or 100% of their daily stabilisation dose, and a placebo, in a double-blind, cross-over design. Twenty patients completed the study, all were assessed pre- and post-drug on 2 separate testing days. Results: Performance on a task tapping episodic memory (delayed recall of a prose passage) was significantly impaired following the 100% daily dose of methadone. Methadone treatment had no effect on craving or mood. Patients were unable to distinguish between methadone and placebo treatments. Conclusions: A single dose of methadone can induce episodic memory impairment in patients who have a history of heroin use averaging more than 10 years. Such impairment can be avoided by giving methadone in divided doses.