GABAergic excitation in the basolateral amygdala
GABAergic excitation in the basolateral amygdala
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DOI：
10.1523/jneurosci.3389-06.2006
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发表时间：
2006-11-15
影响因子：
5.3
通讯作者：
Sah, Pankaj
中科院分区：
文献类型：
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作者：
Woodruff, Alan R.;Monyer, Hannah;Sah, Pankaj
含gaba的中间神经元是一种多样化的细胞群，其在成熟神经系统中的主要作用方式是抑制突触后靶神经元。通过对基底外侧杏仁核小白蛋白阳性中间神经元的成对记录，我们发现，在中间神经元亚群中，一个中间神经元的单一动作电位在突触后中间神经元中引起单突触抑制性突触电流，随后是双突触兴奋性谷氨酸能突触电流。神经元间诱发的谷氨酸能事件可被AMPA/kainate或GABA(A)受体拮抗剂阻断，并可同时出现在突触前和突触后的中间神经元中。这些结果表明，gaba能中间神经元的单个动作电位可以驱动谷氨酸能主神经元达到阈值，从而产生前馈和反馈兴奋。在中间神经元对都接受谷氨酸能输入后，相对于其他中间神经元对，电偶联和双向gaba能连接发生的概率更高。我们提出，这种形式的gaba能激发提供了一种可靠的和特异性的招募同质中间神经元网络在基底杏仁核。
GABA-containing interneurons are a diverse population of cells whose primary mode of action in the mature nervous system is inhibition of postsynaptic target neurons. Using paired recordings from parvalbumin-positive interneurons in the basolateral amygdala, we show that, in a subpopulation of interneurons, single action potentials in one interneuron evoke in the postsynaptic interneuron a monosynaptic inhibitory synaptic current, followed by a disynaptic excitatory glutamatergic synaptic current. Interneuron-evoked glutamatergic events were blocked by antagonists of either AMPA/kainate or GABA(A) receptors, and could be seen concurrently in both presynaptic and postsynaptic interneurons. These results show that single action potentials in a GABAergic interneuron can drive glutamatergic principal neurons to threshold, resulting in both feedforward and feedback excitation. In interneuron pairs that both receive glutamatergic inputs after an interneuron spike, electrical coupling and bidirectional GABAergic connections occur with a higher probability relative to other interneuron pairs. We propose that this form of GABAergic excitation provides a means for the reliable and specific recruitment of homogeneous interneuron networks in the basal amygdala.