Investigation of silicon carbon nitride nanocomposite films as a wear resistant layer in vitro and in vivo for joint replacement applications
Investigation of silicon carbon nitride nanocomposite films as a wear resistant layer in vitro and in vivo for joint replacement applications
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DOI：
10.1016/j.colsurfb.2017.02.010
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发表时间：
2017-05-01
影响因子：
5.8
通讯作者：
Tu, J. P.
中科院分区：
文献类型：
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作者：
Liang, Y.;Liu, D. G.;Tu, J. P.
采用离子束辅助磁控溅射在不同氮气压力下制备了含硅CNx纳米复合薄膜。随着氮气压力的增加，CNx薄膜的硅和氮含量急剧增加，当P-N2达到40%左右时达到饱和。表面粗糙度和接触角增大，而摩擦系数减小。 Si含量为5.7 at.%的CR薄膜具有最低的摩擦系数，仅为0.07，并表现出最好的摩擦学性能。比较不同硅含量的CNx薄膜与Ti6Al4V薄膜对成骨细胞生长和活化的影响。 CR 薄膜中硅的掺入也显示出细胞粘附力的增加。粘合结构和表面能被确定为有助于改善生物相容性的因素。附着在含有 5.7 at.% Si 的 CNx 膜上的巨噬细胞下调了细胞因子和趋化因子的产生。此外，采用含Si CNx涂层的关节置换物，将其皮下植入Sprague-Dawley小鼠体内长达36天，与Ti6Al4V相比，组织反应和关节囊形成显着减少。一项小鼠植入研究表明，用于关节置换的耐磨层具有出色的体内生物相容性和功能可靠性，使用硅掺杂 a-CNx 涂层可维持 36 天。 (C) 2017 Elsevier B.V. 保留所有权利。
Silicon-contained CNx nanocomposite films were prepared using the ion beam assisted magnetron sputtering under different nitrogen gas pressure. With increase of the nitrogen pressure, silicon and nitrogen content of the CNx films drastically increase, and is saturated as the P-N2 reach about 40%. Surface roughness and the contact angle are increase, while the friction coefficient decreased. The CR, film with 5.7 at.% Si content possess the lowest friction coefficient of only 0.07, and exhibited the best tribological properties. The impact of CNx films with different silicon content on the growth and the activation of osteoblasts were compared to that of Ti6Al4V. The incorporation of silicon in the CR, film also showed an increase cell adhesion. Bonding structure and surface energy were determined to be the factors contributing to the improved biocompatibility. Macrophages attached to 5.7 at.% Si contained CNx films down regulated their production of cytokines and chemokines. Moreover, employed with Si contained CNx coated joint replacements, which were implanted subcutaneously into Sprague-Dawley mice for up to 36 days, the tissue reaction and capsule formation was significantly decreased compared to that of Ti6Al4V. A mouse implantation study demonstrated the excellent in vivo biocompatibility and functional reliability of wear resist layer for joint replacements with a Si doped a-CNx coating for 36 days. (C) 2017 Elsevier B.V. All rights reserved.