NATURAL AND EXPERIMENTAL INFECTION OF DOGS WITH REOVIRUS, TYPE 1 - PATHOGENICITY OF STRAIN FOR OTHER ANIMALS
NATURAL AND EXPERIMENTAL INFECTION OF DOGS WITH REOVIRUS, TYPE 1 - PATHOGENICITY OF STRAIN FOR OTHER ANIMALS
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DOI：
10.1093/oxfordjournals.aje.a120320
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发表时间：
1963-01-01
影响因子：
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通讯作者：
WENNER, HA
中科院分区：
文献类型：
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作者：
LOU, TY;WENNER, HA
从一只死于呼吸道感染2周的狗身上分离出一株呼肠孤病毒1型。在猴肾细胞中，该病毒产生的胞浆内包涵体与Lang（呼肠孤病毒，l型）株感染后观察到的包涵体相似。实验感染的幼犬出现呼吸道症状。自然感染和实验感染的狗都患上了间质性肺炎；支气管上皮可见胞浆内包涵体。大约三分之一的正常成年狗体内存在可测量的中和抗体。狗肺病毒株虽然在猴子、兔子、猪、仓鼠或雪貂身上几乎没有产生任何临床症状，但可能在大多数物种的组织中传播，因为病毒是从各种组织中恢复的，并且在这些动物中经常产生同型抗体。该病毒可使小鼠患病；没有人试图使这种病毒适应老鼠。结论：呼肠孤病毒1型可能是犬种的另一种病毒性病原体。(作为)。
A strain of reovirus type 1 was isolated from a dog which died 2 weeks after onset of a respiratory infection. In monkey-kidney cells this virus produced intracytoplasmic inclusion bodies similar to those observed after infection with Lang (reovirus, type l) strain. Experimentally infected puppies developed respiratory symptoms. Both naturally and experimentally infected dogs developed interstitial pneumonitis; intracytoplasmic inclusion bodies were found in the bronchial epithelium. Measurable amounts of neutralizing antibodies were present in about one-third of normal adult dogs. The dog-lung strain of virus, although producing few, if any, clinical signs in monkeys, rabbits, g.pigs, hamsters or ferrets, probably propagated in tissues of most species since the virus was recovered from various tissues and homotypic antibodies often developed in these animals. The virus may produce illness in mice; no attempt was made to adapt the virus to mice. It is concluded that reovirus type l is probably another viral pathogen of canine species. (AS).