Galactosaminogalactan of Aspergillus fumigatus, a bioactive fungal polymer
Galactosaminogalactan of Aspergillus fumigatus, a bioactive fungal polymer
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DOI：
10.3852/15-312
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发表时间：
2016-05-01
期刊：
影响因子：
2.8
通讯作者：
Fontaine, Thierry
中科院分区：
文献类型：
--
作者：
Briard, Benoit;Muszkieta, Laetitia;Fontaine, Thierry
半乳糖胺半乳聚糖（GAG）是由机会性人类真菌病原体烟曲霉菌丝体产生的细胞外多糖。GAG是医学真菌学中第一个被描述为毒力因子的多糖。本文综述了目前对该聚合物的结构、组织和生物合成的研究进展。该分子作为一种粘附素的功能也将被强调，这种粘附素也可以掩盖曲霉的PAMPs，以及GAG通过诱导中性粒细胞减少和阻断IL-1信号通路对宿主免疫反应的调节的影响。
Galactosaminogalactan (GAG) is an extracellular polysaccharide produced by the mycelium of the opportunistic human fungal pathogen Aspergillus fumigatus. GAG is the first polysaccharide described as a virulence factor in medical mycology. This review presents our current knowledge of the structural organization and biosynthesis of this polymer. The function of this molecule as an adhesin that also masks Aspergillus PAMPs and the impact of GAG on the modulation of the host immune response by inducing neutropenia and blocking the IL-1 signaling pathway also will be emphasised.