Synthesis, structural determination and protective effects on cultured anoxia/reoxygen injury myocardiocytes of ocotillol-type derivatives
Synthesis, structural determination and protective effects on cultured anoxia/reoxygen injury myocardiocytes of ocotillol-type derivatives
复制标题
奥克替洛尔类衍生物的合成、结构测定及其对培养缺氧/复氧损伤心肌细胞的保护作用
DOI：
10.5897/jmpr11.1125
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发表时间：
2011-06-04
影响因子：
--
通讯作者：
Meng, Qingguo
中科院分区：
文献类型：
--
作者：
Bi, Yi;Tian, Jingwei;Meng, Qingguo
The octillol-type derivatives 3 and its epimer 4 had been designed and synthesized from 20(S)-panaxadiol. The structures of 3 and 4 were confirmed by ESI-MS, H-1-NMR, C-13-NMR and X-ray diffraction. The crystal data showed the configuration of C-24 of two epimers as R-form (3) and S-form (4, epimer) respectively. Compound 3 was evaluated in vitro for its protective effect on cultured myocardiocytes with anoxia/reoxygen injury and compound 4 had none of this activity.
