Effect of the consumption of a new symbiotic shake on glycemia and cholesterol levels in elderly people with type 2 diabetes mellitus.
Effect of the consumption of a new symbiotic shake on glycemia and cholesterol levels in elderly people with type 2 diabetes mellitus.
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DOI：
10.1186/1476-511x-11-29
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发表时间：
2012-02-22
影响因子：
4.5
通讯作者：
Sivieri K
中科院分区：
文献类型：
--
作者：
Moroti C;Souza Magri LF;de Rezende Costa M;Cavallini DC;Sivieri K
考虑到调查其对老年人影响的研究数量有限，含有益生菌和益生元成分的食品的消费量每年都在持续增长。本研究的目的是评估老年人食用含有嗜酸乳杆菌、两歧双歧杆菌和低聚果糖的共生奶昔对血脂和胆固醇水平的影响。对20名年龄在50至60岁的志愿者（安慰剂组10名，共生组10名）进行随机、双盲、安慰剂对照研究。纳入研究的标准是：总胆固醇> 200 mg/dL;甘油三酯> 200 mg/dL和甘油三酯> 110 mg/dL。在30天的总测试期间，10名个体（共生组）每天消耗200 mL的共生奶昔，其中含有108 UFC/mL嗜酸乳杆菌，108 UFC/mL两歧双歧杆菌和2 g低聚果糖，而其他10名志愿者（安慰剂组）每天饮用相同量的奶昔，不含任何共生细菌。在实验开始前15天和开始摇动摄入后每隔10天采集血样。通过酶比色测定法评价标准血脂（总胆固醇、甘油三酯和HDL胆固醇）和甘油三酯或血糖水平。结果显示，共生组的总胆固醇和甘油三酯降低不显著（P > 0.05），HDL胆固醇显著升高（P < 0.05），空腹胆固醇显著降低（P < 0.05）。在安慰剂组中未观察到显著变化。共生摇的消费导致HDL的显着增加和HDL的显着降低。ClinicalTrials.gov：NCT00123456
The consumption of foods containing probiotic and prebiotic ingredients is growing consistently every year, and in view of the limited number of studies investigating their effect in the elderly. The objective of this study was to evaluate the effect of the consumption of a symbiotic shake containing Lactobacillus acidophilus, Bifidobacterium bifidum and fructooligosaccharides on glycemia and cholesterol levels in elderly people. A randomized, double-blind, placebo-controlled study was conducted on twenty volunteers (ten for placebo group and ten for symbiotic group), aged 50 to 60 years. The criteria for inclusion in the study were: total cholesterol > 200 mg/dL; triglycerides > 200 mg/dL and glycemia > 110 mg/dL. Over a total test period of 30 days, 10 individuals (the symbiotic group) consumed a daily dose of 200 mL of a symbiotic shake containing 108 UFC/mL Lactobacillus acidophilus, 108 UFC/mL Bifidobacterium bifidum and 2 g oligofructose, while 10 other volunteers (the placebo group) drank daily the same amount of a shake that did not contain any symbiotic bacteria. Blood samples were collected 15 days prior to the start of the experiment and at 10-day intervals after the beginning of the shake intake. The standard lipid profile (total cholesterol, triglycerides and HDL cholesterol) and glycemia, or blood sugar levels, were evaluated by an enzyme colorimetric assay. The results of the symbiotic group showed a non-significant reduction (P > 0.05) in total cholesterol and triglycerides, a significant increase (P < 0.05) in HDL cholesterol and a significant reduction (P < 0.05) in fasting glycemia. No significant changes were observed in the placebo group. The consumption of symbiotic shake resulted in a significant increase in HDL and a significant decrease of glycemia. ClinicalTrials.gov: NCT00123456