Evaluation of nuclear PGAM2 value in hepatocellular carcinoma prognosis.
Evaluation of nuclear PGAM2 value in hepatocellular carcinoma prognosis.
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DOI：
10.1097/cad.0000000000001150
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发表时间：
2022-01-01
影响因子：
2.3
通讯作者：
Jin RM
中科院分区：
文献类型：
--
作者：
Li YR;Chen JD;Zhu YY;Li JT;Jin GZ;Jin RM
补充数字内容可在正文中找到。磷酸甘油酸变位酶(PGAM)是糖酵解过程中的关键酶。PGAM2在多种组织和恶性肿瘤中含量丰富。然而，关于它们在发育不良结节和肝细胞癌中的临床病理意义的信息有限。本研究旨在探讨PGAM2作为一种新的肝细胞癌生物标志物的预后价值。采用免疫组织化学方法检测10例肝硬变、15例低度异型增生结节、15例高度异型增生结节和20例肝癌组织及178对肝细胞癌及癌旁肝组织中PGAM2的表达水平。根据预后分析结果选择X-Tile软件统计切点进行预后分析，采用Kaplan-Meier分析和Cox回归分析对临床病理参数进行预后评估。癌旁肝组织中核PGAM2的表达显著高于肝细胞癌组织(P=0.0010)。对178例肝癌组织的Kaplan-Meier分析显示，胞核PGAM2‘S高表达与良好的总生存率(OS)显著相关，而胞浆PGAM2无显著相关性。此外，单因素和多因素COX分析表明，核PGAM2的表达可作为预测肝癌OS的有价值的指标。PgAM2在肝细胞癌组织中的表达高于在肝硬变组织中的表达，且核PgAM2‘S高表达可能提示肝细胞癌患者术后预后较差。因此，核PGAM2可作为预测肝癌患者术后OS的有价值的指标。
Supplemental Digital Content is available in the text. Phosphoglycerate mutase (PGAM) is a critical enzyme in glycolysis. PGAM2 is abundant in several types of tissues and malignant tumours. However, there is limited information regarding their clinicopathological significance in dysplastic nodules and hepatocellular carcinoma (HCC). This study aims to investigate the prognostic value of PGAM2 as a new biomarker for HCC. The PGAM2 expression level was evaluated by immunohistochemistry in liver cirrhosis (n = 10), low-grade dysplastic nodules (n = 15), high-grade dysplastic nodules (n = 15) and HCCs (n = 20) and 178 pairs of HCC and adjacent peritumoral liver tissues. We selected X-tile software for counting cut-point based on the outcomes for prognosis analysis, and used Kaplan–Meier analysis and Cox regression analysis can assess the prognosis of clinicopathologic parameters. Nuclear PGAM2 was significantly overexpressed in peritumoral liver tissues compared with HCC tissues (P = 0.0010). Kaplan–Meier analyses of 178 HCC samples revealed that nuclear PGAM2’s high expression level, but not cytoplasmic PGAM2, was significantly related to good overall survival rate (OS). In addition, univariate and multivariate Cox analyses indicated nuclear PGAM2 expression could be regarded as valuable predictors for OS in HCC. PGAM2 was highly expressed in HCC tissues than liver cirrhosis tissues, and nuclear PGAM2’s high expression might demonstrate HCC patients have poor postoperative results. Thus, nuclear PGAM2 can be regarded as valuable predictors for OS in HCC patients after surgery.