Hepatic Resection Followed by Hepatic Arterial Infusion Chemotherapy for Hepatocellular Carcinoma with Intrahepatic Dissemination
Hepatic Resection Followed by Hepatic Arterial Infusion Chemotherapy for Hepatocellular Carcinoma with Intrahepatic Dissemination
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DOI：
10.21873/anticanres.12254
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发表时间：
2018-01-01
影响因子：
2
通讯作者：
Baba, Hideo
中科院分区：
文献类型：
--
作者：
Kuramoto, Kunitaka;Beppu, Toru;Baba, Hideo
背景/目的：探讨肝切除术后辅助肝动脉输注化疗（HAIC）对局部消融后肝内播散性肝癌（IHD）患者的应用价值。患者和方法：12例HCC合并IHD患者分为两组：HAIC组（n=6）行肝切除术后HAIC；非haic组（n=6）单独行肝切除术。顺铂+ 5-氟尿嘧啶HAIC在1个月内开始，持续1个月。结果：首次局部消融时，发现肿瘤靠近门静脉8例（67.7%），发现消融不充分6例（58.3%）。HAIC组1年、3年和5年无病生存率和总生存率分别为50.0%、16.7%和16.7%,83.3%、83.3%和62.5%。经过10年的随访，HAIC组中有3例患者仍然存活。结论：肝切除术后短期HAIC可为HCC合并IHD患者提供良好的预后。
Background/Aim: To investigate the utility of adjuvant hepatic arterial infusion chemotherapy (HAIC) following hepatectomy for patients with hepatocellular carcinoma (HCC) with intrahepatic dissemination (IHD) after local ablation therapy. Patients and Methods: Twelve patients with HCC with IHD were divided into two groups: HAIC group (n=6) underwent hepatectomy followed by HAIC; and the non-HAIC group (n=6) underwent hepatectomy alone. HAIC with cisplatin and 5-fluorouracil was started within a month and was continued for a month: Results: At the first local ablation, tumors close to the major portal vein and insufficient ablation were recognized in eight (67.7%) and six (58.3%) of the patients, respectively. In the HAIC group, the 1-, 3-, and 5-year disease-free and overall survival rates were 50.0%, 16.7%, and 16.7%, and 83.3%, 83.3% and 62.5%, respectively. Three patients in the HAIC group remain alive after 10 years of follow-up. Conclusion: Hepatic resection with short-term postoperative HAIC may provide excellent outcomes in patients with HCC and IHD.